Discordant placental echogenicity: A novel sign of impaired placental perfusion in twin-twin transfusion syndrome?

Juan Pedro Kusanovic, Roberto Romero, Francesca Gotsch, Pooja Mittal, Offer Erez, Chong Jai Kim, Sonia S. Hassan, Jimmy Espinoza, Lami Yeo

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Twin-twin transfusion syndrome (TTTS) is present in approximately 5-15% of monochorionic-diamniotic twin pregnancies. A chronic blood flow imbalance through placental vascular anastomoses from the donor to the recipient twin is considered the pathophysiologic mechanism responsible for the development of TTTS. Discordant echogenicity between the donor and recipient placenta has been proposed in a previous case report as an additional sonographic sign of TTTS. Here, we present a case of TTTS with discordant placental echogenicity characterized by a hyperechoic and thicker placental side in the donor twin associated with reduced vascular Doppler signals, histologic lesions suggestive of ischemic changes, and overexpression of anti-angiogenic factors.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume23
Issue number1
DOIs
StatePublished - 1 Jan 2010
Externally publishedYes

Keywords

  • Angiogenesis
  • Anti-angiogenic state
  • Endoglin
  • Monochorionic
  • Placenta
  • Placental growth factor
  • TTTS
  • VEGFR-1

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