Disseminated mucormycosis masquerading as rejection early after orthotopic heart transplantation

Lindsay Margoles; David DeNofrio; Ayan R. Patel; Yoav Golan; Amanda R. Vest; Knarik Arkun; Helen W. Boucher; Michael S. Kiernan; Jenica N. Upshaw

doi:10.1111/tid.12820

Disseminated mucormycosis masquerading as rejection early after orthotopic heart transplantation

Lindsay Margoles, David DeNofrio, Ayan R. Patel, Yoav Golan, Amanda R. Vest, Knarik Arkun, Helen W. Boucher, Michael S. Kiernan, Jenica N. Upshaw

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Mucorales organisms are an uncommon cause of invasive fungal infections after solid organ transplantation but are associated with great morbidity and mortality. We report a fatal case of disseminated Cunninghamella infection early after heart transplantation. The patient developed graft dysfunction and elevated markers of myocyte injury and autopsy revealed fulminant fungal myocarditis. This case highlights the need for a high index of suspicion in immunocompromised patients who are not improving with standard antimicrobial therapy.

Original language	English
Article number	e12820
Journal	Transplant Infectious Disease
Volume	20
Issue number	1
DOIs	https://doi.org/10.1111/tid.12820
State	Published - 1 Feb 2018
Externally published	Yes

Keywords

fungal infections
heart transplantation
mucormycosis

ASJC Scopus subject areas

Infectious Diseases
Transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/tid.12820

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title = "Disseminated mucormycosis masquerading as rejection early after orthotopic heart transplantation",

abstract = "Mucorales organisms are an uncommon cause of invasive fungal infections after solid organ transplantation but are associated with great morbidity and mortality. We report a fatal case of disseminated Cunninghamella infection early after heart transplantation. The patient developed graft dysfunction and elevated markers of myocyte injury and autopsy revealed fulminant fungal myocarditis. This case highlights the need for a high index of suspicion in immunocompromised patients who are not improving with standard antimicrobial therapy.",

keywords = "fungal infections, heart transplantation, mucormycosis",

author = "Lindsay Margoles and David DeNofrio and Patel, {Ayan R.} and Yoav Golan and Vest, {Amanda R.} and Knarik Arkun and Boucher, {Helen W.} and Kiernan, {Michael S.} and Upshaw, {Jenica N.}",

note = "Publisher Copyright: {\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",

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doi = "10.1111/tid.12820",

language = "English",

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T1 - Disseminated mucormycosis masquerading as rejection early after orthotopic heart transplantation

AU - Margoles, Lindsay

AU - DeNofrio, David

AU - Patel, Ayan R.

AU - Golan, Yoav

AU - Vest, Amanda R.

AU - Arkun, Knarik

AU - Boucher, Helen W.

AU - Kiernan, Michael S.

AU - Upshaw, Jenica N.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Mucorales organisms are an uncommon cause of invasive fungal infections after solid organ transplantation but are associated with great morbidity and mortality. We report a fatal case of disseminated Cunninghamella infection early after heart transplantation. The patient developed graft dysfunction and elevated markers of myocyte injury and autopsy revealed fulminant fungal myocarditis. This case highlights the need for a high index of suspicion in immunocompromised patients who are not improving with standard antimicrobial therapy.

AB - Mucorales organisms are an uncommon cause of invasive fungal infections after solid organ transplantation but are associated with great morbidity and mortality. We report a fatal case of disseminated Cunninghamella infection early after heart transplantation. The patient developed graft dysfunction and elevated markers of myocyte injury and autopsy revealed fulminant fungal myocarditis. This case highlights the need for a high index of suspicion in immunocompromised patients who are not improving with standard antimicrobial therapy.

KW - fungal infections

KW - heart transplantation

KW - mucormycosis

UR - http://www.scopus.com/inward/record.url?scp=85040729939&partnerID=8YFLogxK

U2 - 10.1111/tid.12820

DO - 10.1111/tid.12820

M3 - Article

C2 - 29172240

AN - SCOPUS:85040729939

SN - 1398-2273

VL - 20

JO - Transplant Infectious Disease

JF - Transplant Infectious Disease

IS - 1

M1 - e12820

ER -

Disseminated mucormycosis masquerading as rejection early after orthotopic heart transplantation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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