Dissolvable polyvinyl-alcohol film, a time-barrier to modulate sample flow in a 3D-printed holder for capillary flow paper diagnostics

Dorin Harpaz, Tim Axelrod, Alicia Lu Yitian, Evgeni Eltzov, Robert S. Marks, Alfred I.Y. Tok

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Integrating a dissolvable membrane into a sensor allows the control of sample flow, location and duration in critical areas. These time-barrier films stop the flow of samples until the membrane has dissolved, thus, for example, allowing increased exposure time between immunoreagents for the formation of greater numbers of immuno-complexes, ensuring higher sensitivity, reactivity, and helping to reduce false-positive signals. In this study, dissolvable polyvinyl alcohol (PVA) films are used in a 3D-printed sensor holder, which enables film integration without the use of glue. PVA is a synthetic hydrophilic linear polymer, its solubility is dependent on its molecular weight and degree of hydrolysis. Three types of PVAs films were tested herein: (1) PVA 1-Mw: 30-70 K, 87-90% hydrolyzed; (2) PVA 2-Mw: 31-50 K, 98-99% hydrolyzed and (3) PVA 3-Mw: 89-98 K, > 99% hydrolyzed. The films were exposed to water in (1) the novel 3D-printed holder and (2) directly immersed into a water droplet. After comparing the time taken to dissolve PVA 1-3 films, PVA 1 films of 5-20% (w/v) are found to be most suitable as time barrier films, due to their optimal dissolution times and physical properties for integration into the customized 3Dprinted holder.

Original languageEnglish
Article number343
JournalMaterials
Volume12
Issue number3
DOIs
StatePublished - 22 Jan 2019

Keywords

  • 3D-printed holder
  • Dissolvable membrane
  • Paper based sensors
  • Polyvinyl alcohol
  • Sample flow control
  • Time barrier film

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