Abstract
Growing bacteria are sensitive to various β-lactam derivatives due to their interference with peptidoglycan biosynthesis. At low concentrations, penicillin G (benzylpenicillin) blocks cell division without affecting mass growth rate. The MIC for division of Escherichia coli B/r (H266) was found to depend on the growth rate, which was modified by the nutritional conditions. Our hypothesis, that division sensitivity is proportional to the rate of peptidoglycan synthesis for septum formation, as well as to cell circumference, was thus confirmed.
| Original language | English |
|---|---|
| Pages (from-to) | 1081-1083 |
| Number of pages | 3 |
| Journal | Microbiology |
| Volume | 141 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1 Jan 1995 |
Keywords
- Escherichia coli
- FtsZ ring
- Penicillin G
- Penicillin-binding proteins
- β-lactam
ASJC Scopus subject areas
- Microbiology