DNA-based random number generation in security circuitry

Christy M. Gearheart, Benjamin Arazi, Eric C. Rouchka

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


DNA-based circuit design is an area of research in which traditional silicon-based technologies are replaced by naturally occurring phenomena taken from biochemistry and molecular biology. This research focuses on further developing DNA-based methodologies to mimic digital data manipulation. While exhibiting fundamental principles, this work was done in conjunction with the vision that DNA-based circuitry, when the technology matures, will form the basis for a tamper-proof security module, revolutionizing the meaning and concept of tamper-proofing and possibly preventing it altogether based on accurate scientific observations. A paramount part of such a solution would be self-generation of random numbers. A novel prototype schema employs solid phase synthesis of oligonucleotides for random construction of DNA sequences; temporary storage and retrieval is achieved through plasmid vectors. A discussion of how to evaluate sequence randomness is included, as well as how these techniques are applied to a simulation of the random number generation circuitry. Simulation results show generated sequences successfully pass three selected NIST random number generation tests specified for security applications.

Original languageEnglish
Pages (from-to)208-214
Number of pages7
Issue number3
StatePublished - 1 Jun 2010


  • DNA-based circuit design
  • Oligonucleotide synthesis
  • Random number generation
  • Security circuitry

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • General Biochemistry, Genetics and Molecular Biology
  • Applied Mathematics


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