DNA Melting in Poor Solvent

Debjyoti Majumdar

Research output: Contribution to journalArticlepeer-review


The melting phase diagram of a double-stranded DNA in poor solvent is studied using the pruned and enriched Rosenbluth method on a simple cubic lattice. As the solvent quality is changed from good to poor, there is a non-monotonic change in the melting temperature. First-order melting transition, as in good solvent, gives way to continuous transition and then to further broadened transitions where the order parameter smoothly becomes zero for sufficiently poor solvent. This change in the melting behavior is accompanied by a continuously varying critical exponent along the melting curve, hinting at a non-universal nature of the melting transition. Further, we show that an unbound phase can be achieved just by changing the solvent quality. Importantly, our results conform to the experimental findings qualitatively.

Original languageEnglish
Article number14
JournalJournal of Statistical Physics
Issue number1
StatePublished - 1 Jan 2023
Externally publishedYes


  • DNA
  • Monte Carlo
  • Phase transition
  • Polymer

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Mathematical Physics


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