Do poor-responder patients undergoing IVF benefit from splitting and increasing the daily gonadotropin dose?

Osnat Ezra, Jigal Haas, Ravit Nahum, Ettie Maman, Yoram Cohen, Aliza Segev-Zahav, Raoul Orvieto

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We aim to retrospectively evaluate the role of increasing the gonadotropin daily dose from 450 IU/day to 300 IU twice a day on IVF-ET outcome in poor responder patients. All consecutive women admitted to our IVF unit and underwent COH consisting of daily gonadotropin dose of 450 IU, followed by an IVF cycle using 300 IU twice a day, were included. Ovarian stimulation characteristics, number of oocytes retrieved, number of embryo transferred and pregnancy rate was assessed. Twenty-three patients undergoing both cycles were evaluated. While there was no between-group difference in the duration of COH, number of 2PN embryos, fertilization rate and number of embryos transferred, patients receiving daily gonadotropin 300 IU twice a day achieved a significantly higher peak estradiol levels (3350.39 ± 2364.26 vs. 2223.74 ± 1299.91; p <.03, respectively), and yielded significantly higher number of follicles >15 mm in diameter on day of hCG administration (3.2 ± 2.4 vs 1.8 ± 1; p <.03, respectively) and higher number of oocytes retrieved (3.48 ± 2.54 vs 1.87 ± 1.1; p <.02, respectively) with an acceptable live birth rate (5%). To conclude, in poor responders undergoing COH a daily gonadotropin dose of 450 IU, increasing the dose to 300 IU twice daily may result in higher oocyte yield, with the possible improvement in IVF outcome.

Original languageEnglish
Pages (from-to)890-893
Number of pages4
JournalGynecological Endocrinology
Issue number10
StatePublished - 3 Oct 2019
Externally publishedYes


  • Controlled ovarian hyperstimulation
  • IVF
  • gonadotropin daily dose
  • poor responders

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Obstetrics and Gynecology


Dive into the research topics of 'Do poor-responder patients undergoing IVF benefit from splitting and increasing the daily gonadotropin dose?'. Together they form a unique fingerprint.

Cite this