Does day-3 LH/FSH ratio influence in vitro fertilization outcome in PCOS patients undergoing controlled ovarian hyperstimulation with different GnRH-analogue

Raoul Orvieto, Simion Meltcer, Gad Liberty, Jacob Rabinson, Eyal Y. Anteby, Ravit Nahum

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

In an attempt to evaluate whether high basal day-3 luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio affects IVF cycle outcome in polycystic ovary syndrome (PCOS) patients undergoing ovarian stimulation with either GnRH-agonist (n47) or antagonist (n104), we studied 151 IVF cycles: 119 in patients with basal LH/FSH <2 and 32 in patients with LH/FSH ≥2. The PCOS with high LH/FSH ratio achieved a non-significantly higher pregnancy rate using the GnRH-agonist (50% vs 17.9%, p0.2; respectively), as compared to the GnRH-antagonist protocols, probably due to the ability of the long GnRH-agonist protocol to induce a prolong and sustained reduction of the high basal LH milieu and avert its detrimental effect on oocyte quality and implantation potential.

Original languageEnglish
Pages (from-to)422-424
Number of pages3
JournalGynecological Endocrinology
Volume28
Issue number6
DOIs
StatePublished - 1 Jun 2012

Keywords

  • Day-3 LH/FSH ratio
  • GnRH-agonist
  • GnRH-antagonist
  • IVF outcome
  • PCOS
  • Pregnancy

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