Does estrogen directly modulate anti-müllerian hormone secretion in women?

Gad Liberty, Avraham Ben-Chetrit, Ehud J. Margalioth, Jordana H. Hyman, Narine Galoyan, Talia Eldar-Geva

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Objective: To investigate whether estrogen may modulate anti-müllerian hormone (AMH) expression in women. Design: Prospective analysis. Setting: Fertility clinic of tertiary university hospital. Patient(s): Cycling infertile women. Intervention(s): Blood samples were taken at the early, middle, and late follicular phase in five groups: spontaneous cycle (n = 10), ovulation induction with clomiphene-citrate (n = 15) or gonadotropins (n = 9), controlled ovarian hyperstimulation for IVF (COH-IVF; n = 10) and in women who were treated with exogenous E2 for frozen-thawed embryo-transfer (FET) with no follicular development (n = 20). Main Outcome Measure(s): AMH and E2 serum levels. Result(s): Basal serum AMH and E2 levels were similar in all groups. AMH levels were stable in all women during the follicular phase except for significant reduction in the COH-IVF group. In women in the FET group with high E2 levels, comparable to the COH-IVF group, AMH levels remained stable. Conclusion(s): In women, estrogen does not appear to have a direct role in AMH regulation.

Original languageEnglish
Pages (from-to)2253-2256
Number of pages4
JournalFertility and Sterility
Volume94
Issue number6
DOIs
StatePublished - 1 Nov 2010
Externally publishedYes

Keywords

  • AMH expression
  • Estrogen
  • modulation

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