Does lipid infusion affect bile composition in humans?

M. Rubin, R. Pakula, A. Moser, Z. Halpern, M. Shimonov, D. Lichtenberg

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A study was performed to investigate the effect of short-term lipid infusion on bile composition and its lithogenicity in humans. Forty-four patients scheduled for laparotomy were treated with a lipid emulsion of either long chain triglycerides (LCT) or a mixture of medium and long chain triglycerides (LCT/MCT) or with glucose-saline. Bile samples were obtained by puncture of the gallbladder during operation. Among other results, it was found that both lipids caused an elevation of biliary cholesterol and phospholipids in non-gallstone patients, but this effect was more pronounced with the mixture of MCT/LCT emulsion. The fatty acid composition of biliary phospholipids was not affected by either lipid infusion.

Original languageEnglish
Pages (from-to)1308-1313
Number of pages6
JournalIsrael Journal of Medical Sciences
Issue number12
StatePublished - 1 Dec 1996
Externally publishedYes


  • Bile
  • Lipid emulsion
  • Total parenteral nutrition

ASJC Scopus subject areas

  • Bioengineering


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