Abstract
Neuroleptic treatment of schizophrenia reduces CSF cyclic AMP in clinical responders after a mean of 8 weeks of treatment. This is consistent with continued effective dopamine receptor blockade by these drugs. Rat striatal 3H-spiroperidol binding sites increase more after 10 weeks of haloperidol therapy than after 3 weeks, suggesting that physiological equilibrium has not yet been reached by 3 weeks. The rat striatal receptor affinity for 3H-spiroperidol is decreased after 10 weeks but not after 3 weeks. The decreased affinity represents a new phenomenon that may be important in explaining long-term continuing neuroleptic effectiveness despite the increased receptor number. The decreased affinity of rat dopamine binding sites for 3H-spiroperidol after 10 weeks of neuroleptic treatment is consistent with the reduced human CSF cyclic AMP after a similar period of neuroleptic treatment.
Original language | English |
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Pages (from-to) | 109-118 |
Number of pages | 10 |
Journal | Progress in biochemical pharmacology |
Volume | 16 |
State | Published - 1 Dec 1980 |
ASJC Scopus subject areas
- General Medicine