Dopamine receptors in a rat model of minimal brain dysfunction

J. Eisenberg, E. Brecher-Fride, R. Weizman, R. P. Ebstein, R. H. Belmaker

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A model of minimal brain dysfunction (MBD) in rats based on injection of 6-OH-dopamine (DA) intracistemally on the 5th day of life has been described previously. Since 6-OH-DA pretreatment has been reported in adult rats to lead to a compensatory rise in DA receptor number, we measured DA receptor number in animals treated with 6-OH-DA on the 5th day of life, after completion of behavioral observations on days 17, 20 and 23 of life. Rats pretreated with 6-OH-DA at day 5 were found, on sacrifice on day 23, to have a mean increase of about 20% in caudate spiperone binding. There was a significant correlation between spiperone binding and gross activity in 6-OH-DA-treated animals but not in untreated animals. Since the significant correlation between receptor number and gross activity is negative and DA receptor stimulators are known to increase activity, it appears that receptor number changes are not directly related to hyperactivity.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalNeuropsychobiology
Volume8
Issue number3
DOIs
StatePublished - 1 Jan 1982
Externally publishedYes

Keywords

  • Dopamine receptor
  • Hyperactivity
  • Rat MBD 6-OH-dopamine
  • Spiperone

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

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