Doped semiconductor nanocrystal based fluorescent cellular imaging probes

Amit Ranjan Maity, Sharbari Palmal, S. K. Basiruddin, Niladri Sekhar Karan, Suresh Sarkar, Narayan Pradhan, Nikhil R. Jana

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Doped semiconductor nanocrystals such as Mn doped ZnS, Mn doped ZnSe and Cu doped InZnS, are considered as new classes of fluorescent biological probes with low toxicity. Although the synthesis in high quality of such nanomaterials is now well established, transforming them into functional fluorescent probes remains a challenge. Here we report a fluorescent cellular imaging probe made of high quality doped semiconductor nanocrystals. We have identified two different coating approaches suitable for transforming the as synthesized hydrophobic doped semiconductor nanocrystals into water-soluble functional nanoparticles. Following these approaches we have synthesized TAT-peptide- and folate-functionalized nanoparticles of 10-80 nm hydrodynamic diameter and used them as a fluorescent cell label. The results shows that doped semiconductor nanocrystals can be an attractive alternative for conventional cadmium based quantum dots with low toxicity.

Original languageEnglish
Pages (from-to)5506-5513
Number of pages8
Issue number12
StatePublished - 21 Jun 2013
Externally publishedYes

ASJC Scopus subject areas

  • General Materials Science


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