Dose-response of intermittent theta burst stimulation of the prefrontal cortex: A TMS-EEG study

Manon Desforges, Itay Hadas, Brian Mihov, Yan Morin, Mathilde Rochette Braün, Pantelis Lioumis, Reza Zomorrodi, Hugo Théoret, Martin Lepage, Zafiris J. Daskalakis, Sara Tremblay

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objective: Using concurrent transcranial magnetic stimulation (TMS) and electroencephalography (TMS-EEG), this study aims to compare the effect of three intermittent theta-burst stimulation (iTBS) doses on cortical activity in the left dorsolateral prefrontal (DLPFC) cortex. Methods: Fourteen neurotypical participants took part in the following three experimental conditions: 600, 1200 and 1800 pulses. TMS-EEG recordings were conducted on the left DLPFC pre/post iTBS, including single-pulse TMS and short- and long-interval intracortical inhibition (SICI, LICI). TMS-evoked potentials (TEP) and event-related spectral perturbation (ERSP) were quantified. Linear mixed models were used to assess the effect of iTBS on brain activity. Results: The effects of iTBS on DLPFC activity did not significantly differ between the three doses. Specifically, regardless of dose, iTBS modulated the amplitude of most TEP components (P30, N45, P60, P200), reduced SICI and LICI ratios of P30 and P200, and decreased ERSP power of theta oscillations. Conclusions: In neurotypical individuals, doubling or tripling the number of iTBS pulses does not result in stronger potentiation of prefrontal activity. However, all iTBS conditions induced significant modulations of DLPFC activity. Significance: Replicating the study in clinical populations could help define optimal parameters for clinical applications.

Original languageEnglish
Pages (from-to)158-172
Number of pages15
JournalClinical Neurophysiology
StatePublished - 1 Apr 2022
Externally publishedYes


  • Dorsolateral prefrontal cortex
  • Healthy subjects
  • Neuroplasticity
  • iTBS
  • rTMS

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Sensory Systems
  • Physiology (medical)


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