TY - JOUR
T1 - Dose-response of intermittent theta burst stimulation of the prefrontal cortex
T2 - A TMS-EEG study
AU - Desforges, Manon
AU - Hadas, Itay
AU - Mihov, Brian
AU - Morin, Yan
AU - Rochette Braün, Mathilde
AU - Lioumis, Pantelis
AU - Zomorrodi, Reza
AU - Théoret, Hugo
AU - Lepage, Martin
AU - Daskalakis, Zafiris J.
AU - Tremblay, Sara
N1 - Publisher Copyright:
© 2022 International Federation of Clinical Neurophysiology
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Objective: Using concurrent transcranial magnetic stimulation (TMS) and electroencephalography (TMS-EEG), this study aims to compare the effect of three intermittent theta-burst stimulation (iTBS) doses on cortical activity in the left dorsolateral prefrontal (DLPFC) cortex. Methods: Fourteen neurotypical participants took part in the following three experimental conditions: 600, 1200 and 1800 pulses. TMS-EEG recordings were conducted on the left DLPFC pre/post iTBS, including single-pulse TMS and short- and long-interval intracortical inhibition (SICI, LICI). TMS-evoked potentials (TEP) and event-related spectral perturbation (ERSP) were quantified. Linear mixed models were used to assess the effect of iTBS on brain activity. Results: The effects of iTBS on DLPFC activity did not significantly differ between the three doses. Specifically, regardless of dose, iTBS modulated the amplitude of most TEP components (P30, N45, P60, P200), reduced SICI and LICI ratios of P30 and P200, and decreased ERSP power of theta oscillations. Conclusions: In neurotypical individuals, doubling or tripling the number of iTBS pulses does not result in stronger potentiation of prefrontal activity. However, all iTBS conditions induced significant modulations of DLPFC activity. Significance: Replicating the study in clinical populations could help define optimal parameters for clinical applications.
AB - Objective: Using concurrent transcranial magnetic stimulation (TMS) and electroencephalography (TMS-EEG), this study aims to compare the effect of three intermittent theta-burst stimulation (iTBS) doses on cortical activity in the left dorsolateral prefrontal (DLPFC) cortex. Methods: Fourteen neurotypical participants took part in the following three experimental conditions: 600, 1200 and 1800 pulses. TMS-EEG recordings were conducted on the left DLPFC pre/post iTBS, including single-pulse TMS and short- and long-interval intracortical inhibition (SICI, LICI). TMS-evoked potentials (TEP) and event-related spectral perturbation (ERSP) were quantified. Linear mixed models were used to assess the effect of iTBS on brain activity. Results: The effects of iTBS on DLPFC activity did not significantly differ between the three doses. Specifically, regardless of dose, iTBS modulated the amplitude of most TEP components (P30, N45, P60, P200), reduced SICI and LICI ratios of P30 and P200, and decreased ERSP power of theta oscillations. Conclusions: In neurotypical individuals, doubling or tripling the number of iTBS pulses does not result in stronger potentiation of prefrontal activity. However, all iTBS conditions induced significant modulations of DLPFC activity. Significance: Replicating the study in clinical populations could help define optimal parameters for clinical applications.
KW - Dorsolateral prefrontal cortex
KW - Healthy subjects
KW - iTBS
KW - Neuroplasticity
KW - rTMS
KW - TMS-EEG
UR - http://www.scopus.com/inward/record.url?scp=85126002215&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2021.12.018
DO - 10.1016/j.clinph.2021.12.018
M3 - Article
C2 - 35183861
AN - SCOPUS:85126002215
SN - 1388-2457
VL - 136
SP - 158
EP - 172
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
ER -