Double-blind, controlled trial of inositol treatment of depression

Joseph Levine, Yoram Barak, Mirtha Gonzalves, Henry Szor, Avner Elizur, Ora Kofman, R. H. Belmaker

Research output: Contribution to journalArticlepeer-review

197 Scopus citations


Objective: CSF levels of inositol have been reported to be lower than normal in depressed subjects. The authors administered inositol to depressed patients in a double-blind, controlled trial. Method: Under double-blind conditions, 12 g/day of inositol (N=13) or placebo (N=15) was administered to depressed patients for 4 weeks. Results: The overall improvement in scores on the Hamilton Depression Rating Scale was significantly greater for inositol than for placebo at week 4. No changes were noted in hematology or in kidney or liver function. Conclusions: This may be the first use of the precursor strategy for a second messenger rather than a neurotransmitter in treating depression. Although inositol had a significant antidepressant effect in this study, replication is crucial.

Original languageEnglish
Pages (from-to)792-794
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number5
StatePublished - 1 Jan 1995

ASJC Scopus subject areas

  • Psychiatry and Mental health


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