Drug development and the use of induced pluripotent stem cell-derived cardiomyocytes for disease modeling and drug toxicity screening

Paz Ovics, Danielle Regev, Polina Baskin, Mor Davidor, Yuval Shemer, Shunit Neeman, Yael Ben-Haim, Ofer Binah

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Over the years, numerous groups have employed human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) as a superb human-compatible model for investigating the function and dysfunction of cardiomyocytes, drug screening and toxicity, disease modeling and for the development of novel drugs for heart diseases. In this review, we discuss the broad use of iPSC-CMs for drug development and disease modeling, in two related themes. In the first theme—drug development, adverse drug reactions, mechanisms of cardiotoxicity and the need for efficient drug screening protocols—we discuss the critical need to screen old and new drugs, the process of drug development, marketing and Adverse Drug reactions (ADRs), drug-induced cardiotoxicity, safety screening during drug development, drug development and patient-specific effect and different mechanisms of ADRs. In the second theme—using iPSC-CMs for disease modeling and developing novel drugs for heart diseases—we discuss the rationale for using iPSC-CMs and modeling acquired and inherited heart diseases with iPSC-CMs.

Original languageEnglish
Article number7320
Pages (from-to)1-42
Number of pages42
JournalInternational Journal of Molecular Sciences
Volume21
Issue number19
DOIs
StatePublished - 1 Oct 2020
Externally publishedYes

Keywords

  • Adverse Drug Reactions (ADRs)
  • Cardiotoxiciy
  • Channelopathies
  • Drug screening
  • IPSC-CMs
  • Laminopathies
  • Metabolic mutations
  • Structural mutations

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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