Drug disposition in spontaneously hypertensive rats

Z. Ben-Zvi; J. Kaplanski; D. Warszawski

doi:10.1016/S0031-6989(80)80050-6

Drug disposition in spontaneously hypertensive rats

Z. Ben-Zvi, J. Kaplanski, D. Warszawski

Basic Sciences Divisions

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Abstract

Drug metabolism was investigated in spontaneously hypertensive rats in vivo and in vitro. Glucuronyl transferase activity in vitro was lower in spontaneously hypertensive rats than normotensive rats, while oxidative drug metabolizing enzyme were not different. On the other hand, in vivo oxidative metabolism was higher in spontaneously hypertensive rats than in normotensive rats as measured by hexobarbital sleeping time. The possible contribution of hemodynamic factors that occur in the hypertensive state to the higher rate of drug oxidation in vivo is discussed.

Original language	English
Pages (from-to)	873-876
Number of pages	4
Journal	Pharmacological Research Communications
Volume	12
Issue number	9
DOIs	https://doi.org/10.1016/S0031-6989(80)80050-6
State	Published - 1 Jan 1980

ASJC Scopus subject areas

Pharmacology

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10.1016/S0031-6989(80)80050-6

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AU - Warszawski, D.

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AB - Drug metabolism was investigated in spontaneously hypertensive rats in vivo and in vitro. Glucuronyl transferase activity in vitro was lower in spontaneously hypertensive rats than normotensive rats, while oxidative drug metabolizing enzyme were not different. On the other hand, in vivo oxidative metabolism was higher in spontaneously hypertensive rats than in normotensive rats as measured by hexobarbital sleeping time. The possible contribution of hemodynamic factors that occur in the hypertensive state to the higher rate of drug oxidation in vivo is discussed.

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Drug disposition in spontaneously hypertensive rats

Abstract

ASJC Scopus subject areas

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