Drug eluting stenting in bifurcation coronary lesions long-term results applying a systematic treatment strategy

Abid R. Assali, Hana Vaknin-Assa, Eli Lev, Igal Teplitsky, Danny Dvir, David Brosh, Tamir Bental, Alexander Battler, Ran Kornowski

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objectives: To explore the long-term results following implantation of drug-eluting stents (DES) in bifurcation lesions according to contemporary "real world" practice. Background: Limited information is available on the long-term outcomes of patients with bifurcation lesions who are treated using DES. A systematic approach for bifurcation lesion management was applied, using either a "provisional" single stent technique or a dedicated two stents strategy according to the side-branch diameter and severity of its ostial stenosis. Methods: Four hundred one consecutive patients underwent bifurcation percutaneous coronary intervention (PCI) using DES and were included in our prospective registry. All adverse events were recorded up to 2 years and distinguished according to the planned PCI strategy (e.g., one versus two stents technique). Results: A planned two stents strategy was used in 141 patients (35% of patients). In 260 patients (65%), the planned treatment involved stenting of the main branch only with "provisional" stenting of the side-branch according to procedural course. Thus, 24 patients (9.2%) needed additional stenting at the side-branch to complete the PCI. Cumulative major adverse cardiac event rate at 1 and 2 years was similar for both groups (11.4% vs. 14.8% at 1 year and 19.4% vs. 25.7% at 2 years for the single vs. two stents groups, accordingly, P = NS for both). Likewise, there was no difference in mortality, cardiac mortality, myocardial infarction, need for target lesions or target vessel revascularization, or definite stent thrombosis rate between the two groups at 6, 12, and 2 years follow-up. The rate of angiographically confirmed (i.e., definite) stent thrombosis did not differ between the two groups during follow-up. Conclusions: Our study revealed favorable long-term clinical results following DES implantation using a systematic, rather simplified approach towards bifurcation stenting and using either a single or double stenting technique.

Original languageEnglish
Pages (from-to)615-622
Number of pages8
JournalCatheterization and Cardiovascular Interventions
Volume79
Issue number4
DOIs
StatePublished - 1 Mar 2012
Externally publishedYes

Keywords

  • bifurcation lesion
  • drug-eluting stent
  • restenosis

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