Dry Eye Disease following LASIK, PRK, and LASEK: An Observational Cross-Sectional Study

Tal Yahalomi, Asaf Achiron, Roee Arnon, Nir Stanescu, Joseph Pikkel

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations


    Dry eye disease is the most frequent non-refractive postoperative complication following refractive surgery. This prospective study investigated the development of dry eye disease after three common refractive laser surgeries: laser in situ keratomileusis (LASIK), photorefractive keratectomy (PRK), and laser-assisted sub-epithelial keratectomy (LASEK). Patients who underwent uneventful refractive surgery in a single private medical center between May 2017 and September 2020 were included. Ocular surface disease was graded according to the Dry Eye Workshop severity (DEWS) classification. Patients were examined 6 months following refractive surgery. The analysis included 251 eyes of 137 patients: 64 eyes (36 patients) after LASEK, 90 eyes (48 patients) after PRK, and 97 eyes (53 patients) after LASIK. At 6 months post-surgery, the DEWS score was higher for the LASIK than the PRK and LASEK groups (p = 0.01). For the total cohort, severe DEWS score (grades 3 and 4) at 6 months post-surgery was correlated with female gender (p = 0.01) and to the amount of refractive correction (p < 0.001), but not to age (p = 0.87). In conclusion, LASIK surgery and female gender were associated with dry eye. Patients, particularly those with high myopia, should be counseled about the risk of developing dry eye after refractive surgeries.

    Original languageEnglish
    Article number3761
    JournalJournal of Clinical Medicine
    Issue number11
    StatePublished - 1 Jun 2023


    • Dry Eye Workshop severity score (DEWS)
    • LASEK
    • LASIK
    • PRK
    • dry eye disease
    • ocular surface disease
    • refractive surgery

    ASJC Scopus subject areas

    • General Medicine


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