Dry Ozonation of Steroids. C-25 Functionalization of Cholestane Derivatives

Zvi Cohen, Yehuda Mazur

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The ozonation of substrates adsorbed on dry silica gel is a convenient method to introduce oxygen into unactivated tertiary C-H bonds. This method involves preadsorption of substrate on chromatographic grade silica gel and passing over it ozone at temperatures between -75 and -45 °C, followed by elution with an appropriate solvent. The reactivity of C-H bonds toward ozone depends both on the electronegativity of the C atom and on its steric availability.

Original languageEnglish
Pages (from-to)2318-2320
Number of pages3
JournalJournal of Organic Chemistry
Issue number13
StatePublished - 1 Feb 1979
Externally publishedYes


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