Dynamic and Responsive DNA-like Polymers

Sudheendran Mavila; Brady T. Worrell; Heidi R. Culver; Trevor M. Goldman; Chen Wang; Chern Hooi Lim; Dylan W. Domaille; Sankha Pattanayak; Matthew K. McBride; Charles B. Musgrave; Christopher N. Bowman

doi:10.1021/jacs.8b09105

Dynamic and Responsive DNA-like Polymers

Sudheendran Mavila, Brady T. Worrell, Heidi R. Culver, Trevor M. Goldman, Chen Wang, Chern Hooi Lim, Dylan W. Domaille, Sankha Pattanayak, Matthew K. McBride, Charles B. Musgrave, Christopher N. Bowman

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

The synthesis of thiolactone monomers that mimic natural nucleosides and engage in robust ring opening polymerizations (ROP) is herein described. As each repeat unit contains a thioester functional group, dynamic rearrangement of the polymer is feasible via thiol-thioester exchange, demonstrated here by depolymerization of the polymers and coalescing of two polymers of different molecular weight or chemical composition. This approach constitutes the first step toward a platform that enables for the routine synthesis of sequence controlled polymers via dynamic template directed synthesis.

Original language	English
Pages (from-to)	13594-13598
Number of pages	5
Journal	Journal of the American Chemical Society
Volume	140
Issue number	42
DOIs	https://doi.org/10.1021/jacs.8b09105
State	Published - 24 Oct 2018
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/jacs.8b09105

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title = "Dynamic and Responsive DNA-like Polymers",

abstract = "The synthesis of thiolactone monomers that mimic natural nucleosides and engage in robust ring opening polymerizations (ROP) is herein described. As each repeat unit contains a thioester functional group, dynamic rearrangement of the polymer is feasible via thiol-thioester exchange, demonstrated here by depolymerization of the polymers and coalescing of two polymers of different molecular weight or chemical composition. This approach constitutes the first step toward a platform that enables for the routine synthesis of sequence controlled polymers via dynamic template directed synthesis.",

author = "Sudheendran Mavila and Worrell, \{Brady T.\} and Culver, \{Heidi R.\} and Goldman, \{Trevor M.\} and Chen Wang and Lim, \{Chern Hooi\} and Domaille, \{Dylan W.\} and Sankha Pattanayak and McBride, \{Matthew K.\} and Musgrave, \{Charles B.\} and Bowman, \{Christopher N.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",

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doi = "10.1021/jacs.8b09105",

language = "English",

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AU - Mavila, Sudheendran

AU - Worrell, Brady T.

AU - Culver, Heidi R.

AU - Goldman, Trevor M.

AU - Wang, Chen

AU - Lim, Chern Hooi

AU - Domaille, Dylan W.

AU - Pattanayak, Sankha

AU - McBride, Matthew K.

AU - Musgrave, Charles B.

AU - Bowman, Christopher N.

PY - 2018/10/24

Y1 - 2018/10/24

N2 - The synthesis of thiolactone monomers that mimic natural nucleosides and engage in robust ring opening polymerizations (ROP) is herein described. As each repeat unit contains a thioester functional group, dynamic rearrangement of the polymer is feasible via thiol-thioester exchange, demonstrated here by depolymerization of the polymers and coalescing of two polymers of different molecular weight or chemical composition. This approach constitutes the first step toward a platform that enables for the routine synthesis of sequence controlled polymers via dynamic template directed synthesis.

AB - The synthesis of thiolactone monomers that mimic natural nucleosides and engage in robust ring opening polymerizations (ROP) is herein described. As each repeat unit contains a thioester functional group, dynamic rearrangement of the polymer is feasible via thiol-thioester exchange, demonstrated here by depolymerization of the polymers and coalescing of two polymers of different molecular weight or chemical composition. This approach constitutes the first step toward a platform that enables for the routine synthesis of sequence controlled polymers via dynamic template directed synthesis.

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M3 - Article

C2 - 30351134

AN - SCOPUS:85054899642

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EP - 13598

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 42

ER -

Dynamic and Responsive DNA-like Polymers

Abstract

ASJC Scopus subject areas

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