Abstract
Background: Present Triglycerides (TG) levels might serve only
as a partial indicator of coronary heart disease (CHD) risk.
Objective: to assess the association of changes over time in fasting TG with CHD risk in young adults.
Design: A follow-up study of 13,953 participants over 5.5 years
in the Staff Periodic Examination Center of the Israel Defense
Force.
Patients: apparently healthy, untreated, young men (26–45 years)
with TG below 300 mg/dL.
Measurements: two follow-up measurements (at enrollment:
Time1, and 3–5 years later: Time 2) of TG and life-style parameters.
Incident outcome cases of angiography-proven CHD.
Results: during 77,066 person-years of follow-up, 158 cases of
CHD were identified. The multivariate model was adjusted for age,
family history, fasting glucose, high-density-lipoprotein, blood pressure, body mass index (BMI) and dynamic changes between Time1
and Time2 of BMI, physical activity, smoking status and eating breakfast. The risk of men with top tertile of TG levels at Time1 was
modified by the subsequent Time2 TG values: [HR 8.23 (95% CI:
2.50–27.13) for High-High, 6.84(95% CI:1.95–23.98) for HighIntermediate, and 4.90 (95% CI: 1.01–24.55) for High-Low, as compared to the stable Low-Low group]. The risk for men with low levels
of TG at Time2 was modified by the previous Time1 values:
[HR 3.88 (95% CI: 1.04–22.50) for Intermediate-Low, and 4.90
(95% CI: 1.01–24.55) for High-Low, as compared to the stable LowLow group].
Conclusions: two TG measurements, 3–5 years apart, may assist
in assessing CHD risk in young men: Decreasing initially elevated TG
levels are associated with decrease of CHD risk, whereas high preceding levels of TG are associated with increase of CHD risk.
as a partial indicator of coronary heart disease (CHD) risk.
Objective: to assess the association of changes over time in fasting TG with CHD risk in young adults.
Design: A follow-up study of 13,953 participants over 5.5 years
in the Staff Periodic Examination Center of the Israel Defense
Force.
Patients: apparently healthy, untreated, young men (26–45 years)
with TG below 300 mg/dL.
Measurements: two follow-up measurements (at enrollment:
Time1, and 3–5 years later: Time 2) of TG and life-style parameters.
Incident outcome cases of angiography-proven CHD.
Results: during 77,066 person-years of follow-up, 158 cases of
CHD were identified. The multivariate model was adjusted for age,
family history, fasting glucose, high-density-lipoprotein, blood pressure, body mass index (BMI) and dynamic changes between Time1
and Time2 of BMI, physical activity, smoking status and eating breakfast. The risk of men with top tertile of TG levels at Time1 was
modified by the subsequent Time2 TG values: [HR 8.23 (95% CI:
2.50–27.13) for High-High, 6.84(95% CI:1.95–23.98) for HighIntermediate, and 4.90 (95% CI: 1.01–24.55) for High-Low, as compared to the stable Low-Low group]. The risk for men with low levels
of TG at Time2 was modified by the previous Time1 values:
[HR 3.88 (95% CI: 1.04–22.50) for Intermediate-Low, and 4.90
(95% CI: 1.01–24.55) for High-Low, as compared to the stable LowLow group].
Conclusions: two TG measurements, 3–5 years apart, may assist
in assessing CHD risk in young men: Decreasing initially elevated TG
levels are associated with decrease of CHD risk, whereas high preceding levels of TG are associated with increase of CHD risk.
| Original language | English GB |
|---|---|
| Pages (from-to) | 261-262 |
| Journal | Annals of Nutrition and Metabolism |
| Volume | 51 |
| State | Published - 2007 |