TY - JOUR
T1 - Dynamic lipidome alterations associated with human health, disease and ageing
AU - Hornburg, Daniel
AU - Wu, Si
AU - Moqri, Mahdi
AU - Zhou, Xin
AU - Contrepois, Kevin
AU - Bararpour, Nasim
AU - Traber, Gavin M.
AU - Su, Baolong
AU - Metwally, Ahmed A.
AU - Avina, Monica
AU - Zhou, Wenyu
AU - Ubellacker, Jessalyn M.
AU - Mishra, Tejaswini
AU - Schüssler-Fiorenza Rose, Sophia Miryam
AU - Kavathas, Paula B.
AU - Williams, Kevin J.
AU - Snyder, Michael P.
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Lipids can be of endogenous or exogenous origin and affect diverse biological functions, including cell membrane maintenance, energy management and cellular signalling. Here, we report >800 lipid species, many of which are associated with health-to-disease transitions in diabetes, ageing and inflammation, as well as cytokine–lipidome networks. We performed comprehensive longitudinal lipidomic profiling and analysed >1,500 plasma samples from 112 participants followed for up to 9 years (average 3.2 years) to define the distinct physiological roles of complex lipid subclasses, including large and small triacylglycerols, ester- and ether-linked phosphatidylethanolamines, lysophosphatidylcholines, lysophosphatidylethanolamines, cholesterol esters and ceramides. Our findings reveal dynamic changes in the plasma lipidome during respiratory viral infection, insulin resistance and ageing, suggesting that lipids may have roles in immune homoeostasis and inflammation regulation. Individuals with insulin resistance exhibit disturbed immune homoeostasis, altered associations between lipids and clinical markers, and accelerated changes in specific lipid subclasses during ageing. Our dataset based on longitudinal deep lipidome profiling offers insights into personalized ageing, metabolic health and inflammation, potentially guiding future monitoring and intervention strategies.
AB - Lipids can be of endogenous or exogenous origin and affect diverse biological functions, including cell membrane maintenance, energy management and cellular signalling. Here, we report >800 lipid species, many of which are associated with health-to-disease transitions in diabetes, ageing and inflammation, as well as cytokine–lipidome networks. We performed comprehensive longitudinal lipidomic profiling and analysed >1,500 plasma samples from 112 participants followed for up to 9 years (average 3.2 years) to define the distinct physiological roles of complex lipid subclasses, including large and small triacylglycerols, ester- and ether-linked phosphatidylethanolamines, lysophosphatidylcholines, lysophosphatidylethanolamines, cholesterol esters and ceramides. Our findings reveal dynamic changes in the plasma lipidome during respiratory viral infection, insulin resistance and ageing, suggesting that lipids may have roles in immune homoeostasis and inflammation regulation. Individuals with insulin resistance exhibit disturbed immune homoeostasis, altered associations between lipids and clinical markers, and accelerated changes in specific lipid subclasses during ageing. Our dataset based on longitudinal deep lipidome profiling offers insights into personalized ageing, metabolic health and inflammation, potentially guiding future monitoring and intervention strategies.
UR - http://www.scopus.com/inward/record.url?scp=85170358518&partnerID=8YFLogxK
U2 - 10.1038/s42255-023-00880-1
DO - 10.1038/s42255-023-00880-1
M3 - Article
C2 - 37697054
AN - SCOPUS:85170358518
SN - 2522-5812
VL - 5
SP - 1578
EP - 1594
JO - Nature Metabolism
JF - Nature Metabolism
IS - 9
ER -