Dysfunctional syndromes and fibromyalgia: A 2012 critical digest

Piercarlo Sarzi-Puttini, Fabiola Atzeni, Manuela Di Franco, Dan Buskila, Alessandra Alciati, Camillo Giacomelli, Alessandra Rossi, Laura Bazzichi

    Research output: Contribution to journalReview articlepeer-review

    33 Scopus citations


    Medically unexplained chronic disorders remain a challenge for clinicians because the patients with these syndromes have a wide range of symptoms, including pain, impaired concentration, sleep disturbances, fatigue and mood disorders, as well as functional problems and difficulties in carrying out the activities of daily living. Such disorders are the result of a complex physiological interaction of central and peripheral nervous signalling that leads to a highly individual symptom complex, although some of them seem to be related to one another, especially in terms of the mechanism of chronicity and pain amplification, and the co-occurrence of fatigue, sleep alterations, mood disturbances and cognitive impairment. This review will discuss the recent literature concerning the most common dysfunctional disorders: fibromyalgia syndrome, myalgic encephalomyelitis/ chronic fatigue syndrome, and irritable bowel syndrome.

    Original languageEnglish
    Pages (from-to)S143-S151
    JournalClinical and Experimental Rheumatology
    Issue numberSUPPL.74
    StatePublished - 1 Dec 2012


    • Dysfunctional syndromes
    • Fibromyalgia


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