Dysplasia and cancer in inflammatory bowel disease 10 years after diagnosis: Results of a population-based European collaborative follow-up study

K. H. Katsanos, S. Vermeire, D. K. Christodoulou, L. Riis, F. Wolters, S. Odes, J. Freitas, Ole Hoie, Marina Beltrami, G. Fornaciari, J. Clofent, P. Bodini, M. Vatn, Paula Borralho Nunes, B. Moum, P. Munkholm, C. Limonard, R. Stockbrugger, P. Rutgeerts, E. V. Tsianos

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Objective: To determine dysplasia and cancer in the 1991-2004 European Collaborative Inflammatory Bowel Disease (EC-IBD) Study Group cohort. Patients and Methods: A patient questionnaire and a physician per patient form were completed for each of the 1,141 inflammatory bowel disease patients (776 ulcerative colitis/365 Crohn's disease) from 9 centers (7 countries) derived from the EC-IBD cohort. Rates of detection of intestinal cancer and dysplasia as well as extra-intestinal neoplasms were computed. Results: Patient follow-up time was 10.3 ± 0.8 (range 9.4-11) years. The mean age of the whole group of IBD patients was 37.8 ± 11.3 (range 16-76) years. Thirty-eight patients (3.3%; 26 with ulcerative colitis/12 with Crohn's disease, 21 males/17 females, aged 61.3 ± 13.4, range 33-77 years), were diagnosed with 42 cancers. Cancers occurred 5.4 ± 3.3 (range 0-11) years after inflammatory bowel disease diagnosis. Colorectal cancer was diagnosed in 8 (1 Crohn's disease and 7 ulcerative colitis patients - 0.3 and 0.9% of the Crohn's disease and ulcerative colitis cohort, respectively) of 38 patients and 30 cancers were extra-intestinal. Four of 38 patients (10.5%) were diagnosed as having 2 cancers and they were younger compared to patients with one cancer (p = 0.0008). There was a trend for a higher prevalence of intestinal cancer in the northern centers (0.9%) compared to southern centers (0.3%, p = NS). Southern centers had more cases of extra-intestinal cancer compared to northern centers (2 vs. 3.8%, p = 0.08). Ten patients (0.9%; 8 with ulcerative colitis/2 with Crohn's disease, 8 males, aged 62.3 ± 14.1 years) had colorectal dysplasia. Conclusions: In the first decade of the EC-IBD Study Group cohort follow-up study, the prevalence of cancer was as expected with most patients having a single neoplasm and an extra-intestinal neoplasm. In northern centers there was a trend for more intestinal cancers, while in southern centers there was a trend for more extra-intestinal cancers compared to northern centers.

Original languageEnglish
Pages (from-to)113-121
Number of pages9
JournalDigestion
Volume75
Issue number2-3
DOIs
StatePublished - 1 Aug 2007

Keywords

  • Cancer
  • Crohn's disease
  • Dysplasia
  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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