TY - JOUR
T1 - Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms
AU - Fonseca, Dennyson Leandro M.
AU - Jäpel, Maj
AU - Gyamfi, Michael Adu
AU - Filgueiras, Igor Salerno
AU - Baiochi, Gabriela Crispim
AU - Ostrinski, Yuri
AU - Halpert, Gilad
AU - Lavi, Yael Bublil
AU - Vojdani, Elroy
AU - Silva-Sousa, Thayna
AU - Usuda, Júlia Nakanishi
AU - E Silva, Juan Carlo Santos
AU - Freire, Paula P.
AU - Nóbile, Adriel Leal
AU - Adri, Anny Silva
AU - Barcelos, Pedro Marçal
AU - Corrêa, Yohan Lucas Gonçalves
AU - do Vale, Fernando Yuri Nery
AU - Lopes, Letícia Oliveira
AU - Schmidt, Solveig Lea
AU - Wang, Xiaoqing
AU - Vahldieck, Carl
AU - Fels, Benedikt
AU - Schimke, Lena F.
AU - Cabral-Miranda, Gustavo
AU - Hirata, Mario Hiroyuki
AU - AKhan, Taj Ali
AU - Yu, Yen Rei A.
AU - Dalmolin, Rodrigo Js
AU - Amital, Howard
AU - Vojdani, Aristo
AU - Dias, Haroldo Dutra
AU - Nakaya, Helder
AU - Ochs, Hans D.
AU - Silverberg, Jonathan I.
AU - Zimmerman, Jason
AU - Zyskind, Israel
AU - Rosenberg, Avi Z.
AU - Schulze-Forster, Kai
AU - Heidecke, Harald
AU - Catar, Rusan
AU - Moll, Guido
AU - Hackel, Alexander
AU - Kusche-Vihrog, Kristina
AU - Shoenfeld, Yehuda
AU - Riemekasten, Gabriela
AU - Akbarzadeh, Reza
AU - Marques, Alexandre H.C.
AU - Cabral-Marques, Otavio
N1 - Publisher Copyright:
© 2025. The Author(s).
PY - 2025/1/13
Y1 - 2025/1/13
N2 - Coronavirus disease 2019 (COVID-19) presents a wide spectrum of symptoms, the causes of which remain poorly understood. This study explored the associations between autoantibodies (AABs), particularly those targeting G protein-coupled receptors (GPCRs) and renin‒angiotensin system (RAS) molecules, and the clinical manifestations of COVID-19. Using a cross-sectional analysis of 244 individuals, we applied multivariate analysis of variance, principal component analysis, and multinomial regression to examine the relationships between AAB levels and key symptoms. Significant correlations were identified between specific AABs and symptoms such as fever, muscle aches, anosmia, and dysgeusia. Notably, anti-AGTR1 antibodies, which contribute to endothelial glycocalyx (eGC) degradation, a process reversed by losartan, have emerged as strong predictors of core symptoms. AAB levels increased with symptom accumulation, peaking in patients exhibiting all four key symptoms. These findings highlight the role of AABs, particularly anti-AGTR1 antibodies, in determining symptom severity and suggest their involvement in the pathophysiology of COVID-19, including vascular complications.
AB - Coronavirus disease 2019 (COVID-19) presents a wide spectrum of symptoms, the causes of which remain poorly understood. This study explored the associations between autoantibodies (AABs), particularly those targeting G protein-coupled receptors (GPCRs) and renin‒angiotensin system (RAS) molecules, and the clinical manifestations of COVID-19. Using a cross-sectional analysis of 244 individuals, we applied multivariate analysis of variance, principal component analysis, and multinomial regression to examine the relationships between AAB levels and key symptoms. Significant correlations were identified between specific AABs and symptoms such as fever, muscle aches, anosmia, and dysgeusia. Notably, anti-AGTR1 antibodies, which contribute to endothelial glycocalyx (eGC) degradation, a process reversed by losartan, have emerged as strong predictors of core symptoms. AAB levels increased with symptom accumulation, peaking in patients exhibiting all four key symptoms. These findings highlight the role of AABs, particularly anti-AGTR1 antibodies, in determining symptom severity and suggest their involvement in the pathophysiology of COVID-19, including vascular complications.
UR - http://www.scopus.com/inward/record.url?scp=85215614185&partnerID=8YFLogxK
U2 - 10.1038/s41540-025-00488-z
DO - 10.1038/s41540-025-00488-z
M3 - Article
C2 - 39805853
AN - SCOPUS:85215614185
SN - 2056-7189
VL - 11
SP - 7
JO - npj Systems Biology and Applications
JF - npj Systems Biology and Applications
IS - 1
ER -