Dysregulation of Cell Signaling by SARS-CoV-2

Rahul K. Suryawanshi, Raghuram Koganti, Alex Agelidis, Chandrashekhar D. Patil, Deepak Shukla

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

Pathogens usurp host pathways to generate a permissive environment for their propagation. The current spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection presents the urgent need to understand the complex pathogen–host interplay for effective control of the virus. SARS-CoV-2 reorganizes the host cytoskeleton for efficient cell entry and controls host transcriptional processes to support viral protein translation. The virus also dysregulates innate cellular defenses using various structural and nonstructural proteins. This results in substantial but delayed hyperinflammation alongside a weakened interferon (IFN) response. We provide an overview of SARS-CoV-2 and its uniquely aggressive life cycle and discuss the interactions of various viral proteins with host signaling pathways. We also address the functional changes in SARS-CoV-2 proteins, relative to SARS-CoV. Our comprehensive assessment of host signaling in SARS-CoV-2 pathogenesis provides some complex yet important strategic clues for the development of novel therapeutics against this rapidly emerging worldwide crisis.

Original languageEnglish
Pages (from-to)224-237
Number of pages14
JournalTrends in Microbiology
Volume29
Issue number3
DOIs
StatePublished - 1 Mar 2021
Externally publishedYes

Keywords

  • COVID-19
  • SARS-CoV-2
  • cell signaling
  • immune response
  • viral proteins

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Dysregulation of Cell Signaling by SARS-CoV-2'. Together they form a unique fingerprint.

Cite this