Early childhood allergy linked with development of attention deficit hyperactivity disorder and autism spectrum disorder

Shay Nemet, Ilan Asher, Israel Yoles, Tuvia Baevsky, Zev Sthoeger

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background: Previous studies reported controversial results regarding the association between allergic disorders and attention deficit hyperactivity disorder (ADHD)/autism spectrum disorder (ASD). The aim of this article was to investigate whether allergic disorders are associated with ADHD/ASD in a large cohort of pediatric patients. Methods: A retrospective study using the pediatric (0–18 year) database (ICD-9-CM codes) of Clalit Health Services during the years (2000–2018). Diagnosis of all disorders was made by specialist physicians. Results: A total of 117 022 consecutive non-selective allergic children diagnosed with one or more allergic disorder (asthma, rhinitis, conjunctivitis, skin, food, or drug allergy) and 116 968 non-allergic children were enrolled to our study. The mean follow-up period was 11 ± 6 years. The presence of allergic disorders in early childhood (mean age of allergic diagnosis 4.5 ± 4.3 years) in boys as well as in girls significantly increased the risk to develop ADHD (O.R 2.45, CI 2.39–2.51; p <.0001), ASD (O.R 1.17, CI 1.08–1.27; p <.0001), or both ADHD + ASD (O.R 1.5, CI 1.35–1.79; p <.0001). Children with more than one allergic comorbidity revealed a much higher risk. In a multivariable analysis (adjusted for age at study entry, number of yearly visits, and gender), the risk of allergic children to develop ADHD and ADHD + ASD, but not ASD alone, remained significantly higher. Conclusion: Allergic disorder in early childhood significantly increased the risk to develop ADHD, and to a less extend ASD, in later life.

Original languageEnglish
Article numberPAI13819
JournalPediatric Allergy and Immunology
Issue number6
StatePublished - 1 Jun 2022
Externally publishedYes


  • ADHD
  • ASD
  • gender
  • pediatric allergic disorders
  • risk factor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology


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