Early delivery following chronic and acute ambient temperature exposure: A comprehensive survival approach

Ian Hough, Matthieu Rolland, Ariane Guilbert, Emie Seyve, Barbara Heude, Remy Slama, Sarah Lyon-Caen, Isabelle Pin, Cecile Chevrier, Itai Kloog, Johanna Lepeule

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: Ambient temperature, particularly heat, is increasingly acknowledged as a trigger for preterm delivery but study designs have been limited and results mixed. We aimed to comprehensively evaluate the association between ambient temperature throughout pregnancy and preterm delivery. Methods: We estimated daily temperature throughout pregnancy using a cutting-edge spatiotemporal model for 5347 live singleton births from three prospective cohorts in France, 2002-2018. We performed Cox regression (survival analysis) with distributed lags to evaluate time-varying associations with preterm birth simultaneously controlling for exposure during the first 26 weeks and last 30 days of pregnancy. We examined weekly mean, daytime, night-Time and variability of temperature, and heatwaves accounting for adaptation to location and season. Results: Preterm birth risk was higher following cold (5th vs 50th percentile of mean temperature) 7-9 weeks after conception [relative risk (RR): 1.3, 95% CI: 1.0-1.6 for 2°C vs 11.6°C] and 10-4 days before delivery (RR: 1.6, 95% CI: 1.1-2.1 for 1.2°C vs 12.1°C). Night-Time heat (95th vs 50th percentile of minimum temperature; 15.7°C vs 7.4°C) increased risk when exposure occurred within 5 weeks of conception (RR: 2.0, 95% CI: 1.05-3.8) or 20-26 weeks after conception (RR: 2.9, 95% CI: 1.2-6.8). Overall and daytime heat (high mean and maximum temperature) showed consistent effects. We found no clear associations with temperature variability or heatwave indicators, suggesting they may be less relevant for preterm birth. Conclusions: In a temperate climate, night-Time heat and chronic and acute cold exposures were associated with increased risk of preterm birth. These results suggest night-Time heat as a relevant indicator. In the context of rising temperatures and more frequent weather hazards, these results should inform public health policies to reduce the growing burden of preterm births.

Original languageEnglish
Pages (from-to)761-773
Number of pages13
JournalInternational Journal of Epidemiology
Volume52
Issue number3
DOIs
StatePublished - 1 Jun 2023

Keywords

  • Preterm birth
  • cold
  • exposure windows
  • heat

ASJC Scopus subject areas

  • Epidemiology

Fingerprint

Dive into the research topics of 'Early delivery following chronic and acute ambient temperature exposure: A comprehensive survival approach'. Together they form a unique fingerprint.

Cite this