Easily generated hematological biomarkers and prediction of placental abruption

Liad Alfandari, Gali Pariente, David Yohay, Ofir Levy, Adi Yehuda Weintraub, Reut Rotem

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objective: Placental abruption (PA) is associated with adverse maternal and neonatal outcomes. Increasing evidence has shown an association between abruption and inflammation as well as utilization of hematological biomarkers to predict the later. We aimed to evaluate the feasibility of using neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ration (PLR) taken early in pregnancy in predicting later occurrence of PA. Study design: A nested case control study, which compared parturient with PA (cases) to parturient without PA (controls). Parturient were matched by hospitalization date and maternal age. Demographic, clinical, and obstetrical characteristics were retrieved. Hematological indices derived from complete blood count taken during the first trimester of pregnancy, specifically NLR and PLR were retrieved and compared between the groups. Mann-Whitney and T-test were performed for not normally and normally distributed continuous variables respectively, categorical variables were analyzed using Chi-Square or Fisher Exact test as appropriate. Results: The study comprised of 232 patients. Of these, 131 had suffered from PA and 131 without PA. Parturient who had PA has significantly higher rates of hypertensive disorders of pregnancy, mean neutrophil, lymphocyte and platelet count did not differ between the groups. A comparison of NLR and PLR between the study groups yielded no significant differences. Conclusion: NLR and PLR taken early in the course of pregnancy were not found associated with PA. Given the potentially severe consequences of PA, the biological plausibility and the readiness of these hematological markers, further investigation of this method with larger, prospective studies are needed.

Original languageEnglish
Article number102082
JournalJournal of Gynecology Obstetrics and Human Reproduction
Issue number8
StatePublished - 1 Oct 2021


  • Hematological indices
  • Neutrophil to lymphocyte ratio
  • Placental abruption
  • Platelet to lymphocyte ratio
  • Predication

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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