TY - JOUR
T1 - Eco-friendly reduced graphene oxide for the determination of mycophenolate mofetil in pharmaceutical formulations
AU - Narayan, Prashanth S.
AU - Teradal, Nagappa L.
AU - Jaldappagari, Seetharamappa
AU - Satpati, Ashis K.
N1 - Funding Information:
We are grateful to the Board of Research in Nuclear Sciences , Mumbai, for financial assistance ( No.2012/37C/8/BRNS/637 dated 28-05-2012). Thanks also go to the authorities of the Karnatak University, Dharwad, for providing the necessary facilities.
Publisher Copyright:
© 2018 Xi'an Jiaotong University
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Graphene oxide (GO) was synthesized and characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM), X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FT-IR) and thermogravimetric analysis (TGA). GO was then electrochemically reduced and used for electrochemical study of mycophenolate mofetil (MMF). The electrochemically reduced graphene oxide (ERGO) film on glassy carbon electrode (GCE) showed enhanced peak current for electrooxidation of MMF. MMF exhibited two irreversible oxidation peaks at 0.84 V (peak a1) and 1.1 V (peak a2). Effects of accumulation time, pH and scan rate were studied and various electrochemical parameters were calculated. A differential pulse voltammetric method was developed for the determination of MMF in bulk samples and pharmaceutical formulations. Linear relationship was observed between the peak current and concentration of MMF in the range of 40 nM–15 μM with a limit of detection of 11.3 nM. The proposed method is simple, sensitive and inexpensive and, hence, could be readily adopted in clinical and quality control laboratories.
AB - Graphene oxide (GO) was synthesized and characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM), X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FT-IR) and thermogravimetric analysis (TGA). GO was then electrochemically reduced and used for electrochemical study of mycophenolate mofetil (MMF). The electrochemically reduced graphene oxide (ERGO) film on glassy carbon electrode (GCE) showed enhanced peak current for electrooxidation of MMF. MMF exhibited two irreversible oxidation peaks at 0.84 V (peak a1) and 1.1 V (peak a2). Effects of accumulation time, pH and scan rate were studied and various electrochemical parameters were calculated. A differential pulse voltammetric method was developed for the determination of MMF in bulk samples and pharmaceutical formulations. Linear relationship was observed between the peak current and concentration of MMF in the range of 40 nM–15 μM with a limit of detection of 11.3 nM. The proposed method is simple, sensitive and inexpensive and, hence, could be readily adopted in clinical and quality control laboratories.
KW - Analytical application
KW - Electrochemical sensor
KW - Electroreduced graphene oxide
KW - Mycophenolate mofetil
UR - http://www.scopus.com/inward/record.url?scp=85042861180&partnerID=8YFLogxK
U2 - 10.1016/j.jpha.2017.12.001
DO - 10.1016/j.jpha.2017.12.001
M3 - Article
AN - SCOPUS:85042861180
VL - 8
SP - 131
EP - 137
JO - Journal of Pharmaceutical Analysis
JF - Journal of Pharmaceutical Analysis
SN - 2095-1779
IS - 2
ER -