Effect of β-alanine supplementation on carnosine and histidine content in the hippocampus of 14-month-old rats

Jay R. Hoffman; John A. Rathmacher; Jennifer Robinson; Yftach Gepner; Hagit Cohen

doi:10.1139/apnm-2019-0102

Effect of β-alanine supplementation on carnosine and histidine content in the hippocampus of 14-month-old rats

Jay R. Hoffman, John A. Rathmacher, Jennifer Robinson, Yftach Gepner, Hagit Cohen

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Carnosine and histidine content in the hippocampus of 14-month-old male rats was examined following 30 days of β-alanine supplementation. All animals were provided identical diets; however, 100 mg of β-alanine was mixed with glucomannan (80:20 blend) in the water of β-alanine supplemented animals. Hippocampal carnosine content was significantly greater (p = 0.005) for β-alanine compared with control, while no differences (p = 0.438) were noted in histidine content between groups. Results provide initial evidence that β-alanine supplementation increases carnosine content in the hippocampus of middle-aged rats, without compromising histidine content. β-Alanine supplementation increases hippocampal carnosine content without compromising histidine content in middle-aged rats.

Original language	English
Pages (from-to)	1112-1115
Number of pages	4
Journal	Applied Physiology, Nutrition and Metabolism
Volume	44
Issue number	10
DOIs	https://doi.org/10.1139/apnm-2019-0102
State	Published - 1 Jan 2019

Keywords

Aging
Brain
Dietary intervention
Health
Middle-age
Nutrition

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Physiology
Nutrition and Dietetics
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1139/apnm-2019-0102

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title = "Effect of β-alanine supplementation on carnosine and histidine content in the hippocampus of 14-month-old rats",

abstract = "Carnosine and histidine content in the hippocampus of 14-month-old male rats was examined following 30 days of β-alanine supplementation. All animals were provided identical diets; however, 100 mg of β-alanine was mixed with glucomannan (80:20 blend) in the water of β-alanine supplemented animals. Hippocampal carnosine content was significantly greater (p = 0.005) for β-alanine compared with control, while no differences (p = 0.438) were noted in histidine content between groups. Results provide initial evidence that β-alanine supplementation increases carnosine content in the hippocampus of middle-aged rats, without compromising histidine content. β-Alanine supplementation increases hippocampal carnosine content without compromising histidine content in middle-aged rats.",

keywords = "Aging, Brain, Dietary intervention, Health, Middle-age, Nutrition",

author = "Hoffman, {Jay R.} and Rathmacher, {John A.} and Jennifer Robinson and Yftach Gepner and Hagit Cohen",

note = "Funding Information: The authors would like to thank Natural Alternatives International (Carlsbad, Calif., USA) for providing support for this study. The funding source had no involvement in data collection, interpretation, or analysis of data, or of writing the report. Publisher Copyright: {\textcopyright} 2019, Canadian Science Publishing. All rights reserved.",

year = "2019",

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doi = "10.1139/apnm-2019-0102",

language = "English",

volume = "44",

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journal = "Applied Physiology, Nutrition and Metabolism",

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T1 - Effect of β-alanine supplementation on carnosine and histidine content in the hippocampus of 14-month-old rats

AU - Hoffman, Jay R.

AU - Rathmacher, John A.

AU - Robinson, Jennifer

AU - Gepner, Yftach

AU - Cohen, Hagit

N1 - Funding Information: The authors would like to thank Natural Alternatives International (Carlsbad, Calif., USA) for providing support for this study. The funding source had no involvement in data collection, interpretation, or analysis of data, or of writing the report. Publisher Copyright: © 2019, Canadian Science Publishing. All rights reserved.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Carnosine and histidine content in the hippocampus of 14-month-old male rats was examined following 30 days of β-alanine supplementation. All animals were provided identical diets; however, 100 mg of β-alanine was mixed with glucomannan (80:20 blend) in the water of β-alanine supplemented animals. Hippocampal carnosine content was significantly greater (p = 0.005) for β-alanine compared with control, while no differences (p = 0.438) were noted in histidine content between groups. Results provide initial evidence that β-alanine supplementation increases carnosine content in the hippocampus of middle-aged rats, without compromising histidine content. β-Alanine supplementation increases hippocampal carnosine content without compromising histidine content in middle-aged rats.

AB - Carnosine and histidine content in the hippocampus of 14-month-old male rats was examined following 30 days of β-alanine supplementation. All animals were provided identical diets; however, 100 mg of β-alanine was mixed with glucomannan (80:20 blend) in the water of β-alanine supplemented animals. Hippocampal carnosine content was significantly greater (p = 0.005) for β-alanine compared with control, while no differences (p = 0.438) were noted in histidine content between groups. Results provide initial evidence that β-alanine supplementation increases carnosine content in the hippocampus of middle-aged rats, without compromising histidine content. β-Alanine supplementation increases hippocampal carnosine content without compromising histidine content in middle-aged rats.

KW - Aging

KW - Brain

KW - Dietary intervention

KW - Health

KW - Middle-age

KW - Nutrition

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U2 - 10.1139/apnm-2019-0102

DO - 10.1139/apnm-2019-0102

M3 - Article

AN - SCOPUS:85072716502

SN - 1715-5312

VL - 44

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EP - 1115

JO - Applied Physiology, Nutrition and Metabolism

JF - Applied Physiology, Nutrition and Metabolism

IS - 10

ER -

Effect of β-alanine supplementation on carnosine and histidine content in the hippocampus of 14-month-old rats

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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