Effect of βblockers on sodium and potassium content of human erythrocytes

I. Nathan, A. Dvilansky, M. Gross, A. D. Korczyn

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Recently, hyperpotassemia was reported in patients treated with propranolol, but the mechanism has not yet been delineated. We have investigated the effects of various βadrenergic blockers and of D-propranolol on the Na+ and K+ distribution intra- and extracellularly in human erythrocytes. K+ loss and Na+ gain by cells was demonstrated at drug concentrations of 10-4 M or greater. D-Propranolol was more effective than L-propranolol, whereas pindolol was ineffective. Practolol increased Na+ content but did not influence K+ The results suggest that electrolyte redistribution across cell membranes is not a likely explanation for hyperpotassemia in patients treated with propranolol, or for the local anaesthetic effect of this drug.

Original languageEnglish
Pages (from-to)935-941
Number of pages7
JournalArchives of Physiology and Biochemistry
Volume87
Issue number5
DOIs
StatePublished - 1 Jan 1979

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