Effect of a Probiotic Infant Formula on Infections in Child Care Centers: Comparison of Two Probiotic Agents

Zvi Weizman, Ghaleb Asli, Аhmed Alsheikh

Research output: Contribution to journalArticlepeer-review


Objective. To investigate the effect of 2 different species of probiotics in preventing infections in infants attending child care centers. Methods. A doubleblind, placebocontrolled, randomized trial was conducted from December 1, 2000, to September 30, 2002, at 14 child care centers in the BeerSheva area of Israel in healthy term infants 4 to 10 months old. Infants were assigned randomly to formula supplemented with Bifidobacterium lactis (BB-12), Lactobacillus reuteri (American Type Culture Collection 55730 (DSM 17938)), or no probiotics. Duration of feeding, including followup, for each participant was 12 weeks. All infants were fed only the assigned formula and were not breastfed due to parental decision before recruitment to the study. Probiotic or prebiotic food products or supplements were not allowed. Main outcome measures were number of days and number of episodes with fever (>38 °C) and number of days and number of episodes with diarrhea or respiratory illness. Results. Participants (n=201) were similar regarding gestational age, birth weight, gender, and previous breastfeeding. The controls (n=60), compared with those fed B. lactis (n=73) or L. reuteri (n=68), had significantly more febrile episodes (mean [95% confidence interval]: 0.41 [0.28–0.54] vs 0.27 [0.17–0.37] vs 0.11 [0.04–0.18], respectively). The controls also had more diarrhea episodes (0.31 [0.22–0.40] vs 0.13 [0.05–0.21] vs 0.02 [0.01–0.05], respectively) and episodes of longer duration (0.59 [0.34–0.84] vs 0.37 [0.08–0.66] vs 0.15 [0.12–0.18] days, respectively). The L. reuteri group, compared with BB-12 or controls, had a significant decrease of number of days with fever, clinic visits, child care absences, and antibiotic prescriptions. Rate and duration of respiratory illnesses did not differ significantly between groups. Conclusions. Child care infants fed a formula supplemented with L. reuteri or B. lactis had fewer and shorter episodes of diarrhea. These effects were more prominent with L. reuteri, which was also the only supplement to improve additional morbidity parameters.

Original languageEnglish
Pages (from-to)25-34
Number of pages10
JournalPaediatrics Eastern Europe
Issue number1
StatePublished - 1 Jan 2019
Externally publishedYes


  • child care
  • infant formula
  • infections
  • probiotics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)


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