Effect of anesthesia on the immune system: Suppression of the immunogenic capacity of macrophages and of lymphocyte transformation

O. Dagan, S. Segal, E. Tzehoval

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Experiments were carried out aimed at investigating the effects of anesthesia without surgery on certain functional components of the immune system. We observed that the immunogenic antigen-presenting capacity of mouse peritoneal macrophages was significantly reduced one week post-anesthesia, with either injected or inhaled anesthetic drugs. On the other hand, an augmentation of the phagocytic activities of these macrophages was manifested. Hence, the impaired immunogenic potency could not be attributed to a reduced antigen uptake. Lymphocyte transformations, i.e., response to PHA and Con A were suppressed, whereas the response to LPS was augmented.

Original languageEnglish
Pages (from-to)975-985
Number of pages11
JournalImmunological Investigations
Volume18
Issue number8
DOIs
StatePublished - 1 Jan 1989

ASJC Scopus subject areas

  • Immunology

Fingerprint

Dive into the research topics of 'Effect of anesthesia on the immune system: Suppression of the immunogenic capacity of macrophages and of lymphocyte transformation'. Together they form a unique fingerprint.

Cite this