TY - JOUR
T1 - Effect of anesthesia on the immune system
T2 - Suppression of the immunogenic capacity of macrophages and of lymphocyte transformation
AU - Dagan, O.
AU - Segal, S.
AU - Tzehoval, E.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - Experiments were carried out aimed at investigating the effects of anesthesia without surgery on certain functional components of the immune system. We observed that the immunogenic antigen-presenting capacity of mouse peritoneal macrophages was significantly reduced one week post-anesthesia, with either injected or inhaled anesthetic drugs. On the other hand, an augmentation of the phagocytic activities of these macrophages was manifested. Hence, the impaired immunogenic potency could not be attributed to a reduced antigen uptake. Lymphocyte transformations, i.e., response to PHA and Con A were suppressed, whereas the response to LPS was augmented.
AB - Experiments were carried out aimed at investigating the effects of anesthesia without surgery on certain functional components of the immune system. We observed that the immunogenic antigen-presenting capacity of mouse peritoneal macrophages was significantly reduced one week post-anesthesia, with either injected or inhaled anesthetic drugs. On the other hand, an augmentation of the phagocytic activities of these macrophages was manifested. Hence, the impaired immunogenic potency could not be attributed to a reduced antigen uptake. Lymphocyte transformations, i.e., response to PHA and Con A were suppressed, whereas the response to LPS was augmented.
UR - https://www.scopus.com/pages/publications/0024316825
U2 - 10.3109/08820138909045784
DO - 10.3109/08820138909045784
M3 - Article
C2 - 2583752
AN - SCOPUS:0024316825
SN - 0882-0139
VL - 18
SP - 975
EP - 985
JO - Immunological Investigations
JF - Immunological Investigations
IS - 8
ER -