TY - JOUR
T1 - Effect of beta-blocker therapy in patients with coronary artery disease in New York heart association classes II and III
AU - Haim, Moti
AU - Shotan, Avraham
AU - Boyko, Valentina
AU - Reicher-Reiss, Henrietta
AU - Benderly, Michal
AU - Goldbourt, Uri
AU - Behar, Solomon
N1 - Funding Information:
This study was supported by an unrestricted grant from Boehringer Mannheim, Mannheim, Germany.
PY - 1998/6/15
Y1 - 1998/6/15
N2 - The aim of the study was to investigate the effect of β-blocker treatment on a large cohort of patients with coronary artery disease in functional classes II and III according to the New York Heart Association (NYHA) classification. Among 11,575 patients with coronary artery disease screened for participation, but not included in the Bezafibrate Infarction Prevention (BIP) study, 3,225 (28%) were in NYHA classes II and III. In the latter group of patients we compared the prognosis of 1,109 (34%) treated with β blockers with 2,116 counterparts not receiving β-blocker therapy. After a mean follow-up of 4 years, all-cause and cardiac mortality rates were significantly lower among β-blocker users, 9% and 5%, respectively, than among β-blocker nonusers, 17% and 11%, respectively (p <0.01 for both). After multivariate adjustment, treatment with β blockers was associated with a lower all-cause mortality risk (hazards ratio [HR] 0.62, 95% confidence interval [CI] 0.49 to 0.78), and a lower cardiac mortality risk (HR = 0.61, 95% CI 0.45 to 0.83) than was no treatment with a β blocker. Lower total mortality risk was noted among patients in NYHA class II (HR 0.63, 95% CI 0.48 to 0.82) and in NYHA class III (HR 0.57, 95% CI 0.37 to 0.87) as well as in patients with (HR 0.62, 95% CI 0.48 to 0.81) or without (HR 0.70, 95% CI 0.45 to 1.09) a previous myocardial infarction. We conclude that β-blocker therapy in coronary patients in NYHA classes II or III is safe and associated with a lower risk for all-cause and cardiac mortality.
AB - The aim of the study was to investigate the effect of β-blocker treatment on a large cohort of patients with coronary artery disease in functional classes II and III according to the New York Heart Association (NYHA) classification. Among 11,575 patients with coronary artery disease screened for participation, but not included in the Bezafibrate Infarction Prevention (BIP) study, 3,225 (28%) were in NYHA classes II and III. In the latter group of patients we compared the prognosis of 1,109 (34%) treated with β blockers with 2,116 counterparts not receiving β-blocker therapy. After a mean follow-up of 4 years, all-cause and cardiac mortality rates were significantly lower among β-blocker users, 9% and 5%, respectively, than among β-blocker nonusers, 17% and 11%, respectively (p <0.01 for both). After multivariate adjustment, treatment with β blockers was associated with a lower all-cause mortality risk (hazards ratio [HR] 0.62, 95% confidence interval [CI] 0.49 to 0.78), and a lower cardiac mortality risk (HR = 0.61, 95% CI 0.45 to 0.83) than was no treatment with a β blocker. Lower total mortality risk was noted among patients in NYHA class II (HR 0.63, 95% CI 0.48 to 0.82) and in NYHA class III (HR 0.57, 95% CI 0.37 to 0.87) as well as in patients with (HR 0.62, 95% CI 0.48 to 0.81) or without (HR 0.70, 95% CI 0.45 to 1.09) a previous myocardial infarction. We conclude that β-blocker therapy in coronary patients in NYHA classes II or III is safe and associated with a lower risk for all-cause and cardiac mortality.
UR - http://www.scopus.com/inward/record.url?scp=0032525840&partnerID=8YFLogxK
U2 - 10.1016/S0002-9149(98)00205-7
DO - 10.1016/S0002-9149(98)00205-7
M3 - Article
AN - SCOPUS:0032525840
SN - 0002-9149
VL - 81
SP - 1455
EP - 1460
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 12
ER -