Effect of bioactive phytochemicals from phlomis viscosa poiret on wound healing

Ludmila Yarmolinsky, Arie Budovsky, Leonid Yarmolinsky, Boris Khalfin, Vladimir Glukhman, Shimon Ben-Shabat

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Phlomis viscosa Poiret is an evergreen shrub growing in Israel, Turkey, Lebanon, and Syria with acknowledged pro-wound healing (WH) properties. In this study, we evaluated the pro-WH potential of selected compounds found in this plant. Among the pro-WH compounds (identified by us) was a combination of three chemicals—diosmin, 1-octen-3-ol, and himachala-2,4-diene which enhanced WH significantly both in in vitro and in vivo models. The determined phytochemicals combination could be used for the treatment of chronic wounds. The effect of the extracts, diosmin, 1-octen-3-ol on the secretion of pro-inflammatory cytokines, IL-6 (A) and IL-8 (B) by human dermal fibroblasts was significant (p < 0.001). In addition, the beneficial effect of extracts of P. viscosa and its phytochemicals on WH was evidenced by inhibiting the growth of several WH delaying microorganisms.

Original languageEnglish
Article number609
Issue number12
StatePublished - 1 Dec 2019


  • Phlomis viscosa
  • Wound healing

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Plant Science


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