Effect of bioactive phytochemicals from phlomis viscosa poiret on wound healing

Ludmila Yarmolinsky; Arie Budovsky; Leonid Yarmolinsky; Boris Khalfin; Vladimir Glukhman; Shimon Ben-Shabat

doi:10.3390/plants8120609

Effect of bioactive phytochemicals from phlomis viscosa poiret on wound healing

Ludmila Yarmolinsky, Arie Budovsky, Leonid Yarmolinsky, Boris Khalfin, Vladimir Glukhman, Shimon Ben-Shabat

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Phlomis viscosa Poiret is an evergreen shrub growing in Israel, Turkey, Lebanon, and Syria with acknowledged pro-wound healing (WH) properties. In this study, we evaluated the pro-WH potential of selected compounds found in this plant. Among the pro-WH compounds (identified by us) was a combination of three chemicals—diosmin, 1-octen-3-ol, and himachala-2,4-diene which enhanced WH significantly both in in vitro and in vivo models. The determined phytochemicals combination could be used for the treatment of chronic wounds. The effect of the extracts, diosmin, 1-octen-3-ol on the secretion of pro-inflammatory cytokines, IL-6 (A) and IL-8 (B) by human dermal fibroblasts was significant (p < 0.001). In addition, the beneficial effect of extracts of P. viscosa and its phytochemicals on WH was evidenced by inhibiting the growth of several WH delaying microorganisms.

Original language	English
Article number	609
Journal	Plants
Volume	8
Issue number	12
DOIs	https://doi.org/10.3390/plants8120609
State	Published - 1 Dec 2019

Keywords

Phlomis viscosa
Wound healing

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Ecology
Plant Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/plants8120609

Cite this

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title = "Effect of bioactive phytochemicals from phlomis viscosa poiret on wound healing",

abstract = "Phlomis viscosa Poiret is an evergreen shrub growing in Israel, Turkey, Lebanon, and Syria with acknowledged pro-wound healing (WH) properties. In this study, we evaluated the pro-WH potential of selected compounds found in this plant. Among the pro-WH compounds (identified by us) was a combination of three chemicals—diosmin, 1-octen-3-ol, and himachala-2,4-diene which enhanced WH significantly both in in vitro and in vivo models. The determined phytochemicals combination could be used for the treatment of chronic wounds. The effect of the extracts, diosmin, 1-octen-3-ol on the secretion of pro-inflammatory cytokines, IL-6 (A) and IL-8 (B) by human dermal fibroblasts was significant (p < 0.001). In addition, the beneficial effect of extracts of P. viscosa and its phytochemicals on WH was evidenced by inhibiting the growth of several WH delaying microorganisms.",

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doi = "10.3390/plants8120609",

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AU - Yarmolinsky, Ludmila

AU - Budovsky, Arie

AU - Yarmolinsky, Leonid

AU - Khalfin, Boris

AU - Glukhman, Vladimir

AU - Ben-Shabat, Shimon

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Phlomis viscosa Poiret is an evergreen shrub growing in Israel, Turkey, Lebanon, and Syria with acknowledged pro-wound healing (WH) properties. In this study, we evaluated the pro-WH potential of selected compounds found in this plant. Among the pro-WH compounds (identified by us) was a combination of three chemicals—diosmin, 1-octen-3-ol, and himachala-2,4-diene which enhanced WH significantly both in in vitro and in vivo models. The determined phytochemicals combination could be used for the treatment of chronic wounds. The effect of the extracts, diosmin, 1-octen-3-ol on the secretion of pro-inflammatory cytokines, IL-6 (A) and IL-8 (B) by human dermal fibroblasts was significant (p < 0.001). In addition, the beneficial effect of extracts of P. viscosa and its phytochemicals on WH was evidenced by inhibiting the growth of several WH delaying microorganisms.

AB - Phlomis viscosa Poiret is an evergreen shrub growing in Israel, Turkey, Lebanon, and Syria with acknowledged pro-wound healing (WH) properties. In this study, we evaluated the pro-WH potential of selected compounds found in this plant. Among the pro-WH compounds (identified by us) was a combination of three chemicals—diosmin, 1-octen-3-ol, and himachala-2,4-diene which enhanced WH significantly both in in vitro and in vivo models. The determined phytochemicals combination could be used for the treatment of chronic wounds. The effect of the extracts, diosmin, 1-octen-3-ol on the secretion of pro-inflammatory cytokines, IL-6 (A) and IL-8 (B) by human dermal fibroblasts was significant (p < 0.001). In addition, the beneficial effect of extracts of P. viscosa and its phytochemicals on WH was evidenced by inhibiting the growth of several WH delaying microorganisms.

KW - Phlomis viscosa

KW - Wound healing

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JO - Plants

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ER -

Effect of bioactive phytochemicals from phlomis viscosa poiret on wound healing

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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