Effect of cannabinoids on the activity of monoamine oxidase in normal human platelets

M. Mazor; A. Dvilansky; M. Aharon; Z. Lazarovitz; I. Nathan

doi:10.3109/13813458209082649

Effect of cannabinoids on the activity of monoamine oxidase in normal human platelets

M. Mazor, A. Dvilansky, M. Aharon, Z. Lazarovitz, I. Nathan

Basic Sciences Divisions

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Platelet MAO activity was affected by preincubation with cannabinoid derivatives in vitro. The psycho-active derivative Δ¹-THC inhibited MAO activity in platelets to an extent varying according to its concentration while CBD and (+ Δ⁶-THC had no inhibitory effect. (-) δ⁶-THC, which is a minor psychomimetic component, had less inhibitory effect on MAO activity than Δ¹-THC. However, (-) DMH Δ⁶-THC revealed no attenuation effect on MAO inspite of its well-known psychomimetic activity.

Original language	English
Pages (from-to)	15-20
Number of pages	6
Journal	Archives of Physiology and Biochemistry
Volume	90
Issue number	1
DOIs	https://doi.org/10.3109/13813458209082649
State	Published - 1 Jan 1982

ASJC Scopus subject areas

Physiology
Physiology (medical)

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abstract = "Platelet MAO activity was affected by preincubation with cannabinoid derivatives in vitro. The psycho-active derivative Δ1-THC inhibited MAO activity in platelets to an extent varying according to its concentration while CBD and (+ Δ6-THC had no inhibitory effect. (-) δ6-THC, which is a minor psychomimetic component, had less inhibitory effect on MAO activity than Δ1-THC. However, (-) DMH Δ6-THC revealed no attenuation effect on MAO inspite of its well-known psychomimetic activity.",

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AU - Dvilansky, A.

AU - Aharon, M.

AU - Lazarovitz, Z.

AU - Nathan, I.

PY - 1982/1/1

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AB - Platelet MAO activity was affected by preincubation with cannabinoid derivatives in vitro. The psycho-active derivative Δ1-THC inhibited MAO activity in platelets to an extent varying according to its concentration while CBD and (+ Δ6-THC had no inhibitory effect. (-) δ6-THC, which is a minor psychomimetic component, had less inhibitory effect on MAO activity than Δ1-THC. However, (-) DMH Δ6-THC revealed no attenuation effect on MAO inspite of its well-known psychomimetic activity.

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Effect of cannabinoids on the activity of monoamine oxidase in normal human platelets

Abstract

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