Abstract
The in-vitro rate of drug metabolizing enzymes was investigated in chronically heat exposed male rats. Exposure to 35±2°C for 30 days resulted in significant reduction in the rates of both hepatic N-demethylation of parachloro-N-methylaniline and aniline hydroxylation. Substantial elevation of rectal temperature and marked reduction in body and liver weights was observed in the same rats. The significance of these results is discussed.
Original language | English |
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Pages (from-to) | 639-642 |
Number of pages | 4 |
Journal | Life Sciences |
Volume | 26 |
Issue number | 8 |
DOIs | |
State | Published - 25 Feb 1980 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Pharmacology, Toxicology and Pharmaceutics