Effect of chronic heat exposure on in-vitro drug metabolism in the rat

Jacob Kaplanski, Zvi Ben-Zvi

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The in-vitro rate of drug metabolizing enzymes was investigated in chronically heat exposed male rats. Exposure to 35±2°C for 30 days resulted in significant reduction in the rates of both hepatic N-demethylation of parachloro-N-methylaniline and aniline hydroxylation. Substantial elevation of rectal temperature and marked reduction in body and liver weights was observed in the same rats. The significance of these results is discussed.

Original languageEnglish
Pages (from-to)639-642
Number of pages4
JournalLife Sciences
Volume26
Issue number8
DOIs
StatePublished - 25 Feb 1980

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Pharmacology, Toxicology and Pharmaceutics

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