Effect of chronic heat exposure on in-vitro drug metabolism in the rat

Jacob Kaplanski; Zvi Ben-Zvi

doi:10.1016/0024-3205(80)90240-4

Effect of chronic heat exposure on in-vitro drug metabolism in the rat

Jacob Kaplanski, Zvi Ben-Zvi

Basic Sciences Divisions

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19 Scopus citations

Abstract

The in-vitro rate of drug metabolizing enzymes was investigated in chronically heat exposed male rats. Exposure to 35±2°C for 30 days resulted in significant reduction in the rates of both hepatic N-demethylation of parachloro-N-methylaniline and aniline hydroxylation. Substantial elevation of rectal temperature and marked reduction in body and liver weights was observed in the same rats. The significance of these results is discussed.

Original language	English
Pages (from-to)	639-642
Number of pages	4
Journal	Life Sciences
Volume	26
Issue number	8
DOIs	https://doi.org/10.1016/0024-3205(80)90240-4
State	Published - 25 Feb 1980

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics

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10.1016/0024-3205(80)90240-4

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title = "Effect of chronic heat exposure on in-vitro drug metabolism in the rat",

abstract = "The in-vitro rate of drug metabolizing enzymes was investigated in chronically heat exposed male rats. Exposure to 35±2°C for 30 days resulted in significant reduction in the rates of both hepatic N-demethylation of parachloro-N-methylaniline and aniline hydroxylation. Substantial elevation of rectal temperature and marked reduction in body and liver weights was observed in the same rats. The significance of these results is discussed.",

author = "Jacob Kaplanski and Zvi Ben-Zvi",

note = "Funding Information: supported by a grant from the Center for Absorption for Immigrant Absorption. State of Israel.",

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AU - Kaplanski, Jacob

AU - Ben-Zvi, Zvi

N1 - Funding Information: supported by a grant from the Center for Absorption for Immigrant Absorption. State of Israel.

PY - 1980/2/25

Y1 - 1980/2/25

N2 - The in-vitro rate of drug metabolizing enzymes was investigated in chronically heat exposed male rats. Exposure to 35±2°C for 30 days resulted in significant reduction in the rates of both hepatic N-demethylation of parachloro-N-methylaniline and aniline hydroxylation. Substantial elevation of rectal temperature and marked reduction in body and liver weights was observed in the same rats. The significance of these results is discussed.

AB - The in-vitro rate of drug metabolizing enzymes was investigated in chronically heat exposed male rats. Exposure to 35±2°C for 30 days resulted in significant reduction in the rates of both hepatic N-demethylation of parachloro-N-methylaniline and aniline hydroxylation. Substantial elevation of rectal temperature and marked reduction in body and liver weights was observed in the same rats. The significance of these results is discussed.

UR - https://www.scopus.com/pages/publications/0019190902

U2 - 10.1016/0024-3205(80)90240-4

DO - 10.1016/0024-3205(80)90240-4

M3 - Article

AN - SCOPUS:0019190902

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SP - 639

EP - 642

JO - Life Sciences

JF - Life Sciences

IS - 8

ER -

Effect of chronic heat exposure on in-vitro drug metabolism in the rat

Abstract

ASJC Scopus subject areas

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