Abstract
In 10 patients with chronic renal failure (CRF), undergoing hemodialysis, we studied respiratory muscle strength and endurance.The data obtained was compared with those acquired from 10age−,sex−, weight− and height−matched normal volunteers. Maximalstatic inspiratory pressures (PImax) measured at residualvolume and maximal static expiratory pressures (PEmax) measured at total lung capacity were significantly lower in the CRF group, 58.2 ± (SD)24.9 and 50.8 ± (SD)24.2% of predicted, respectively (p [ 0.005, p [ 0.01). There was a significant correlation between PImax and PEmax(r = 0.827, p [ 0.001), indicating similar involvement of both inspiratory and expiratory muscle groups. Maximal voluntary ventilation (MVV), although 84.4% of the predicted value in the CRF group, was significantly lower than in the control group, where it was 114% of predicted (p [ 0.001). MVV also correlated significantly with PImax and PEma(r = 0.764, p [ 0.001 and r = 0.807, p [ 0.001, respectively). All but one CRF patient had elevated serum inorganic phosphorus levels, and a significant correlation was found between the serum inorganic phosphorus levels and PImax and PEmax (r = 0.718, p [ 0.001). These data indicate that there is an impairment of respiratory muscle strength and endurance in patients with CRF which may predispose the patient to respiratory muscle fatigue.
Original language | English |
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Pages (from-to) | 153-161 |
Number of pages | 9 |
Journal | Respiration |
Volume | 54 |
Issue number | 3 |
DOIs | |
State | Published - 1 Jan 1988 |
Keywords
- Chronic renal failure
- Maximal expiratory pressure
- Maximal inspiratory pressure
- Respiratory muscle strength
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine