Effect of chronic renal failure on respiratory muscle strength

Hylton Bark, Dov Heimer, Cidio Chaimovitz, Marcus Mostoslovski

    Research output: Contribution to journalArticlepeer-review

    39 Scopus citations


    In 10 patients with chronic renal failure (CRF), undergoing hemodialysis, we studied respiratory muscle strength and endurance.The data obtained was compared with those acquired from 10age−,sex−, weight− and height−matched normal volunteers. Maximalstatic inspiratory pressures (PImax) measured at residualvolume and maximal static expiratory pressures (PEmax) measured at total lung capacity were significantly lower in the CRF group, 58.2 ± (SD)24.9 and 50.8 ± (SD)24.2% of predicted, respectively (p [ 0.005, p [ 0.01). There was a significant correlation between PImax and PEmax(r = 0.827, p [ 0.001), indicating similar involvement of both inspiratory and expiratory muscle groups. Maximal voluntary ventilation (MVV), although 84.4% of the predicted value in the CRF group, was significantly lower than in the control group, where it was 114% of predicted (p [ 0.001). MVV also correlated significantly with PImax and PEma(r = 0.764, p [ 0.001 and r = 0.807, p [ 0.001, respectively). All but one CRF patient had elevated serum inorganic phosphorus levels, and a significant correlation was found between the serum inorganic phosphorus levels and PImax and PEmax (r = 0.718, p [ 0.001). These data indicate that there is an impairment of respiratory muscle strength and endurance in patients with CRF which may predispose the patient to respiratory muscle fatigue.

    Original languageEnglish
    Pages (from-to)153-161
    Number of pages9
    Issue number3
    StatePublished - 1 Jan 1988


    • Chronic renal failure
    • Maximal expiratory pressure
    • Maximal inspiratory pressure
    • Respiratory muscle strength

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine


    Dive into the research topics of 'Effect of chronic renal failure on respiratory muscle strength'. Together they form a unique fingerprint.

    Cite this