Effect of Dexamethasone and Dipyrone on Lingual and Inferior Alveolar Nerve Hypersensitivity Following Third Molar Extractions: Preliminary Report

Robert P. Barron, Raphael Benoliel, Raphael Zeltser, Eli Eliav, Oded Nahlieli, Richard H. Gracely

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Aims: To study the effect of dexamethazone and dipyrone on sensory changes in the innervation territories of the inferior alveolar, infraorbital, and lingual nerves caused by third molar extractions. Methods: Fourteen patients (8 men and 6 women) were divided randomly into 2 groups. The first group received dipyrone preoperatively, while the second group received dipyrone and dexamethazone preoperatively. All patients in the study received a prophylactic preoperative dose of amoxicillin (500 mg) as well as dipyrone postoperatively. In all patients, a single mandibular third molar was removed, while in 2 patients the contralateral third molar was removed at a subsequent time. Electrical detection thresholds were assessed in the inferior alveolar, lingual, and infraorbital nerve regions prior to surgery and 2 and 8 days following surgery. The level of perioperative pain, difficulty of extraction, and distance of molar root apices from the inferior alveolar nerve canal were also assessed. Results: Patients who received only dipyrone had significantly reduced lingual and inferior alveolar nerve electrical detection thresholds 2 days after surgery, which returned to nearly baseline values by the eighth day postoperatively. In patients who received dexamethasone, no significant reduction in the electrical detection threshold was found. Conclusion: Preoperative treatment with dexamethasone and dipyrone but not dipyrone alone prevents sensory hyper sensitivity following third molar extraction.

Original languageEnglish
Pages (from-to)62-68
Number of pages7
JournalJournal of Orofacial Pain
Volume18
Issue number1
StatePublished - 25 Feb 2004
Externally publishedYes

Keywords

  • Dexamethasone
  • Dipyrone
  • Pain measurement
  • Third molar
  • Tooth extraction

ASJC Scopus subject areas

  • General Dentistry
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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