Effect of dibromochloropropane on human testicular function

G. Potashnik, I. Yanai-Inbar, M. I. Sacks, R. Israeli

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Severe impairment of spermatogenesis was found in 18 (78%) of 23 workers after exposure to 1,2-dibromo-3-chloropropane (DBCP). Azoospermia associated with elevated plasma follicle-stimulating hormone was diagnosed in 12 workers whose exposure time to DBCP varied from 100 to >6,000 hr. Oligospermia and normal plasma follicle-stimulating hormone were found in six employees with exposure times between 34 and 95 hr. Plasma luteinizing hormone, testosterone and thyroxine were within the normal range. Testicular biopsy showed slective atrophy of the germinal epithelium, intact Sertoli cells and normal appearance of Leydig cells. The mechanism and potential reversibility of these testicular changes are still to be evaluated.

Original languageEnglish
Pages (from-to)438-442
Number of pages5
JournalIsrael Journal of Medical Sciences
Issue number5
StatePublished - 1 Dec 1979
Externally publishedYes


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