Effect of high-dose, short-duration β-alanine supplementation on circulating IL-10 concentrations during intense military training

Jay R. Hoffman, Yftach Gepner, Mattan W. Hoffman, Hila Zelicha, Shachar Shapira, Ishay Ostfeld

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

This study examined the effect of β-alanine as a potential anti-inflammatory agent during intense military training. Twenty soldiers (20.1 ± 0.6 years) from an elite combat unit were randomly assigned to either a β-Alanine (BA) or placebo (PL) group. Soldiers were provided with 12 g·d -1 of either BA or PL for 7 days between 2 intensive periods of navigational training and restricted sleep. During the initial training period, soldiers navigated on average 27.8 km·d -1 with ;50% of their body mass in their packs for 5 days. Soldiers returned to base and began a 7-day supplementation program before departing for an additional period of intense field training. During the second period of field training, soldiers navigated 10 km·d -1 for an additional 5 days, carrying similar loading as the initial week, performed tactical missions, and slept approximately 5 hours per day. Blood samples were obtained after the initial training period and after the second training period and analyzed for IL-10. Magnitude-based inferences that were used to provide inferences on the true effect BA may have had on IL-10 concentrations compared with PL, calculated from 90% confidence intervals. Data analysis indicated that changes in circulating IL-10 concentrations (mean difference 0.86 pg·ml -1 ) were possibly greater (57%) for BA than PL. Results of this study suggest that 1 week of high-dose BA ingestion may enhance the anti-inflammatory response during intense military training, suggesting a potential therapeutic role of BA during intense training.

Original languageEnglish
Pages (from-to)2978-2981
Number of pages4
JournalJournal of Strength and Conditioning Research
Volume32
Issue number10
DOIs
StatePublished - 1 Oct 2018

Keywords

  • Anti-inflammatory cytokines
  • Carnosine
  • Nutrition
  • Soldiers
  • Stress

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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