Effect of hyaluronidase on cell response to the antiviral and interferon inducing activity of poly(rI) · poly(rC)

Amalia Romano; Ester Ladijinsky; M. Aboud

doi:10.1007/BF01311328

Effect of hyaluronidase on cell response to the antiviral and interferon inducing activity of poly(rI) · poly(rC)

Amalia Romano, Ester Ladijinsky, M. Aboud

The Shraga Segal Department of Microbiology, Immunology and Genetics

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The effect of hyaluronidase on cell response to poly(rI) · poly(rC) [poly(IC)] was investigated in rabbit kidney (RK) cells. For this purpose, bovine testicular and Staphylococcal hyaluronidase preparations at various degrees of purity were used. These enzyme preparations were employed at the maximal nontoxic dose for 2 hours before poly(IC) treatment. This enzymatic pretreatment of the cells strongly inhibited the antiviral activity of poly(IC), determined by using both Herpes simplex virus type-1 and vesicular stomatitis virus. It also remarkably reduced the poly(IC)-induced interferon production. This later effect could account for the diminished antiviral activity of poly(IC) in the hyaluronidase-treated cells.

Original language	English
Pages (from-to)	315-319
Number of pages	5
Journal	Archives of Virology
Volume	78
Issue number	3-4
DOIs	https://doi.org/10.1007/BF01311328
State	Published - 1 Sep 1983

ASJC Scopus subject areas

Virology

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10.1007/BF01311328

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title = "Effect of hyaluronidase on cell response to the antiviral and interferon inducing activity of poly(rI) · poly(rC)",

abstract = "The effect of hyaluronidase on cell response to poly(rI) · poly(rC) [poly(IC)] was investigated in rabbit kidney (RK) cells. For this purpose, bovine testicular and Staphylococcal hyaluronidase preparations at various degrees of purity were used. These enzyme preparations were employed at the maximal nontoxic dose for 2 hours before poly(IC) treatment. This enzymatic pretreatment of the cells strongly inhibited the antiviral activity of poly(IC), determined by using both Herpes simplex virus type-1 and vesicular stomatitis virus. It also remarkably reduced the poly(IC)-induced interferon production. This later effect could account for the diminished antiviral activity of poly(IC) in the hyaluronidase-treated cells.",

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T1 - Effect of hyaluronidase on cell response to the antiviral and interferon inducing activity of poly(rI) · poly(rC)

AU - Romano, Amalia

AU - Ladijinsky, Ester

AU - Aboud, M.

PY - 1983/9/1

Y1 - 1983/9/1

N2 - The effect of hyaluronidase on cell response to poly(rI) · poly(rC) [poly(IC)] was investigated in rabbit kidney (RK) cells. For this purpose, bovine testicular and Staphylococcal hyaluronidase preparations at various degrees of purity were used. These enzyme preparations were employed at the maximal nontoxic dose for 2 hours before poly(IC) treatment. This enzymatic pretreatment of the cells strongly inhibited the antiviral activity of poly(IC), determined by using both Herpes simplex virus type-1 and vesicular stomatitis virus. It also remarkably reduced the poly(IC)-induced interferon production. This later effect could account for the diminished antiviral activity of poly(IC) in the hyaluronidase-treated cells.

AB - The effect of hyaluronidase on cell response to poly(rI) · poly(rC) [poly(IC)] was investigated in rabbit kidney (RK) cells. For this purpose, bovine testicular and Staphylococcal hyaluronidase preparations at various degrees of purity were used. These enzyme preparations were employed at the maximal nontoxic dose for 2 hours before poly(IC) treatment. This enzymatic pretreatment of the cells strongly inhibited the antiviral activity of poly(IC), determined by using both Herpes simplex virus type-1 and vesicular stomatitis virus. It also remarkably reduced the poly(IC)-induced interferon production. This later effect could account for the diminished antiviral activity of poly(IC) in the hyaluronidase-treated cells.

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Effect of hyaluronidase on cell response to the antiviral and interferon inducing activity of poly(rI) · poly(rC)

Abstract

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