Effect of hyperoxia on bronchial response to inhaled methacholine

A. Wollner; L. Ben‐Dov; E. Bar‐Yishay

doi:10.1111/j.1398-9995.1991.tb00540.x

Effect of hyperoxia on bronchial response to inhaled methacholine

A. Wollner, L. Ben‐Dov, E. Bar‐Yishay

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Bronchial reactivity in a double‐blind controlled study in 10 normal subject and nine asthmatic patients. The normal volunteers were challenged while breathing dry. 21% and 100% O₂ and the maximal percent talls in forced expired volume in 1s (FEV₁) following inhalation of the highest concentration of MCH (64 mg/ml) were 8±5% and 9±8% respectively. P−‐ NS. The asthmatic patients had their MCH challenge breathing the same gas composition and the provocative concentrations that caused a 20% fall in FEV₁ (PC.) were 0.18 mg/ml (range 0.06–5.73) and 0.25 mg/ml (range 0.07–8.49) respectively which were statistically not significantly different. We conclude that in humans. 100% O₂ does not affect bronchial reactivity to MCH.

Original language	English
Pages (from-to)	35-39
Number of pages	5
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	46
Issue number	1
DOIs	https://doi.org/10.1111/j.1398-9995.1991.tb00540.x
State	Published - 1 Jan 1991
Externally published	Yes

Keywords

bronchial provocation
bronchial reactivity
inspired air condition
non‐specific reactivity

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1398-9995.1991.tb00540.x

Cite this

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title = "Effect of hyperoxia on bronchial response to inhaled methacholine",

abstract = "Bronchial reactivity in a double‐blind controlled study in 10 normal subject and nine asthmatic patients. The normal volunteers were challenged while breathing dry. 21% and 100% O2 and the maximal percent talls in forced expired volume in 1s (FEV1) following inhalation of the highest concentration of MCH (64 mg/ml) were 8±5% and 9±8% respectively. P−‐ NS. The asthmatic patients had their MCH challenge breathing the same gas composition and the provocative concentrations that caused a 20% fall in FEV1 (PC.) were 0.18 mg/ml (range 0.06–5.73) and 0.25 mg/ml (range 0.07–8.49) respectively which were statistically not significantly different. We conclude that in humans. 100% O2 does not affect bronchial reactivity to MCH.",

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T1 - Effect of hyperoxia on bronchial response to inhaled methacholine

AU - Wollner, A.

AU - Ben‐Dov, L.

AU - Bar‐Yishay, E.

PY - 1991/1/1

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N2 - Bronchial reactivity in a double‐blind controlled study in 10 normal subject and nine asthmatic patients. The normal volunteers were challenged while breathing dry. 21% and 100% O2 and the maximal percent talls in forced expired volume in 1s (FEV1) following inhalation of the highest concentration of MCH (64 mg/ml) were 8±5% and 9±8% respectively. P−‐ NS. The asthmatic patients had their MCH challenge breathing the same gas composition and the provocative concentrations that caused a 20% fall in FEV1 (PC.) were 0.18 mg/ml (range 0.06–5.73) and 0.25 mg/ml (range 0.07–8.49) respectively which were statistically not significantly different. We conclude that in humans. 100% O2 does not affect bronchial reactivity to MCH.

AB - Bronchial reactivity in a double‐blind controlled study in 10 normal subject and nine asthmatic patients. The normal volunteers were challenged while breathing dry. 21% and 100% O2 and the maximal percent talls in forced expired volume in 1s (FEV1) following inhalation of the highest concentration of MCH (64 mg/ml) were 8±5% and 9±8% respectively. P−‐ NS. The asthmatic patients had their MCH challenge breathing the same gas composition and the provocative concentrations that caused a 20% fall in FEV1 (PC.) were 0.18 mg/ml (range 0.06–5.73) and 0.25 mg/ml (range 0.07–8.49) respectively which were statistically not significantly different. We conclude that in humans. 100% O2 does not affect bronchial reactivity to MCH.

KW - bronchial provocation

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KW - inspired air condition

KW - non‐specific reactivity

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Effect of hyperoxia on bronchial response to inhaled methacholine

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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