Effect of inositol treatment on the behavior of rhesus monkeys: Preliminary results

Haim Einat; Joseph Levine; Esther Grauer; Kaimana Macdonald; Robert H. Belmaker

doi:10.1016/S0278-5846(98)00054-2

Effect of inositol treatment on the behavior of rhesus monkeys: Preliminary results

Haim Einat, Joseph Levine, Esther Grauer, Kaimana Macdonald, Robert H. Belmaker

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

1. The effects of inositol (20 g/day, oral) on spatial learning and spontaneous home-cage behavior of four Rhesus monkeys, were studied in a crossover design. 2. Results indicate no marked inositol effect on learning, memory, or behavior. There was a suggestion of an effect of chronic inositol in reducing cage-induced repetitive behavior as indicated by increased switching between modes of behavior, and reduction in length of longest behavioral bout. Furthermore inositol may increase time spent in environmentally-rather than self-oriented behavior. 3. Previous behavioral studies of inositol were performed in rats, which maintain low brain inositol levels compared to primates, including humans. The present study demonstrates the feasibility of primate behavioral studies with inositol, and shows the need for longer time experiments and increased variety of behavioral tests.

Original language	English
Pages (from-to)	999-1005
Number of pages	7
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/S0278-5846(98)00054-2
State	Published - 1 Jan 1998

Keywords

Spatial learning
Spontaneous behavior
Stereotypy
Switching

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/S0278-5846(98)00054-2

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title = "Effect of inositol treatment on the behavior of rhesus monkeys: Preliminary results",

abstract = "1. The effects of inositol (20 g/day, oral) on spatial learning and spontaneous home-cage behavior of four Rhesus monkeys, were studied in a crossover design. 2. Results indicate no marked inositol effect on learning, memory, or behavior. There was a suggestion of an effect of chronic inositol in reducing cage-induced repetitive behavior as indicated by increased switching between modes of behavior, and reduction in length of longest behavioral bout. Furthermore inositol may increase time spent in environmentally-rather than self-oriented behavior. 3. Previous behavioral studies of inositol were performed in rats, which maintain low brain inositol levels compared to primates, including humans. The present study demonstrates the feasibility of primate behavioral studies with inositol, and shows the need for longer time experiments and increased variety of behavioral tests.",

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AU - Belmaker, Robert H.

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KW - Stereotypy

KW - Switching

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Effect of inositol treatment on the behavior of rhesus monkeys: Preliminary results

Abstract

Keywords

ASJC Scopus subject areas

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